Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia
文献类型:期刊论文
作者 | Luo, Na1,2,3; Tian, Lin4; Calhoun, Vince D.5,6,7; Chen, Jiayu5,6; Lin, Dongdong5,6; Vergara, Victor M.5,6; Rao, Shuquan8; Yang, Jian9; Zhuo, Chuanjun10,11; Xu, Yong12 |
刊名 | NEUROIMAGE-CLINICAL |
出版日期 | 2019 |
卷号 | 23期号:2019页码:9 |
ISSN号 | 2213-1582 |
关键词 | Multimodal fusion SNP-FC-GM Schizophrenia stages Sensitivity Duration of illness ICA |
DOI | 10.1016/j.nicl.2019.101887 |
英文摘要 | The progress of schizophrenia at various stages is an intriguing question, which has been explored to some degree using single-modality brain imaging data, e.g. gray matter (GM) or functional connectivity (FC). However it remains unclear how those changes from different modalities are correlated with each other and if the sensitivity to duration of illness and disease stages across modalities is different. In this work, we jointly analyzed FC, GM volume and single nucleotide polymorphisms (SNPs) data of 159 individuals including healthy controls (HC), drug-naive first-episode schizophrenia (FESZ) and chronic schizophrenia patients (CSZ), aiming to evaluate the links among SNP, FC and GM patterns, and their sensitivity to duration of illness and disease stages in schizophrenia. Our results suggested: 1) both GM and FC highlighted impairments in hippocampal, temporal gyrus and cerebellum in schizophrenia, which were significantly correlated with genes like SATB2, GABBR2, PDE4B, CACNA1C etc. 2) GM and FC presented gradually decrease trend (HC > FESZ > CSZ), while SNP indicated a non-gradual variation trend with un-significant group difference observed between FESZ and CSZ; 3) Group difference between HC and FESZ of FC was more remarkable than GM, and FC presented a stronger negative correlation with duration of illness than GM (p = 0.0006). Collectively, these results highlight the benefit of leveraging multimodal data and provide additional clues regarding the impact of mental illness at various disease stages. |
WOS关键词 | GRAY-MATTER ; 1ST EPISODE ; MULTIMODAL FUSION ; CONNECTIVITY ; ABNORMALITIES ; METAANALYSIS ; 1ST-EPISODE ; EXPRESSION ; NAIVE ; ASSOCIATION |
资助项目 | NIH[P20GM103472] ; NIH[R01EB005846] ; National Key R&D Program of China[2017YFC0112000] ; Natural Science Foundation of China[61773380] ; Primary Research & Development Plan of Jiangsu Province[BE2016630] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32040100] ; Beijing Municipal Science and Technology Commission[Z181100001518005] ; Natural Science Foundation of China[81871081] ; NIH[R56MH117107] ; NIH[R01REB020407] |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000485804400076 |
源URL | [http://ir.ia.ac.cn/handle/173211/27295] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Zhang, Fuquan; Sui, Jing |
作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Wuxi Mental Hlth Ctr, Wuxi 214000, Jiangsu, Peoples R China 5.Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA 6.Emory Univ, Atlanta, GA 30303 USA 7.Mind Res Network, Albuquerque, NM 87106 USA 8.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China 9.Beijing Inst Technol, Sch Opt & Elect, Beijing Engn Res Ctr Mixed Real & Adv Display, Beijing, Peoples R China 10.Nankai Univ, Tianjin Mental Hlth Ctr, Affiliated Anding Hosp, Dept Psychiat Neuroimaging Genet, Tianjin 300222, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Na,Tian, Lin,Calhoun, Vince D.,et al. Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia[J]. NEUROIMAGE-CLINICAL,2019,23(2019):9. |
APA | Luo, Na.,Tian, Lin.,Calhoun, Vince D..,Chen, Jiayu.,Lin, Dongdong.,...&Sui, Jing.(2019).Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia.NEUROIMAGE-CLINICAL,23(2019),9. |
MLA | Luo, Na,et al."Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia".NEUROIMAGE-CLINICAL 23.2019(2019):9. |
入库方式: OAI收割
来源:自动化研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。