Progression of cognitive decline before and after incident stroke
文献类型：期刊论文
| 作者 | Zheng, Fanfan1,2 ; Yan, Li3; Zhong, Baoliang4; Yang, Zhenchun3; Xie, Wuxiang3,5
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| 刊名 | NEUROLOGY
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| 出版日期 | 2019-07-02 |
| 卷号 | 93期号:1页码:E20-E28 |
| ISSN号 | 0028-3878 |
| DOI | 10.1212/WNL.0000000000007716 |
| 通讯作者 | Xie, Wuxiang(xiewuxiang@hsc.pku.edu.cn) |
| 英文摘要 | Objective To determine the trajectory of cognitive decline before and after incident stroke. Methods By using data from the English Longitudinal Study of Ageing, we studied 9,278 participants without dementia with no history of stroke who underwent cognitive assessment at baseline (wave 1) and at least 1 other time point (waves 2-7). We used linear mixed models to analyze repeated measures and longitudinal data. Results Among the 9,278 participants (56.8% women, mean age 63.1 +/- 10.3 years), 471 (5.1%) incident stroke events were identified. Compared with stroke-free participants, multivariable-adjusted rates of prestroke cognitive decline in global cognition, memory, semantic fluency, and temporal orientation of participants who later experienced an incident stroke were increased by -0.029, -0.016, -0.022, and -0.024 SD/y, respectively. Among the 471 stroke survivors, the multivariable-adjusted acute changes in the 4 cognitive domains were -0.257, -0.150, -0.121, and -0.272 SD, respectively. In the years after stroke, global cognition declined over time and was steeper than its prestroke slope, that is, by -0.064 SD/y after multivariable adjustment. The rates of memory, semantic fluency, and temporal orientation decline were -0.046, -0.033, and -0.037 SD/y, respectively. Conclusions Accelerated prestroke cognitive decline and poststroke cognitive decline were associated with incident stroke over a follow-up period of 12 years. Attention should be paid to the long-term cognitive problems of stroke survivors, and intervention and management of major vascular risk factors should start from early life or midlife to reduce the risk of cerebrovascular disease and the associated cognitive impairment. |
| WOS关键词 | 1ST-EVER STROKE ; RISK-FACTORS ; IMPAIRMENT ; DEMENTIA ; DISEASE ; PREDICTORS ; ASSOCIATION ; MECHANISMS |
| 资助项目 | National Natural Science Foundation of China[81601176] ; Beijing Natural Science Foundation[7182108] ; Newton International Fellowship from the Academy of Medical Sciences[NIF001-1005-P56804] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000480781000003 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Newton International Fellowship from the Academy of Medical Sciences |
| 源URL | [http://ir.ia.ac.cn/handle/173211/27536]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Xie, Wuxiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.UCL, Inst Cognit Neurosci, London, England 3.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Dept Geriatr Psychiat, Wuhan, Hubei, Peoples R China 5.Peking Univ, Hlth Sci Ctr, Clin Res Inst, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Fanfan,Yan, Li,Zhong, Baoliang,et al. Progression of cognitive decline before and after incident stroke[J]. NEUROLOGY,2019,93(1):E20-E28. |
| APA | Zheng, Fanfan,Yan, Li,Zhong, Baoliang,Yang, Zhenchun,&Xie, Wuxiang.(2019).Progression of cognitive decline before and after incident stroke.NEUROLOGY,93(1),E20-E28. |
| MLA | Zheng, Fanfan,et al."Progression of cognitive decline before and after incident stroke".NEUROLOGY 93.1(2019):E20-E28. |
入库方式： OAI收割
来源：自动化研究所
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