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Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study

文献类型：期刊论文

作者Xie, Sangma1; Liu, Bing2,3,4,5; Wang, Jiaojian6; Zhou, Yuan7,8; Cui, Yue2,3,4; Song, Ming2,3,4; Chen, Yunchun9; Li, Peng10,11; Lui, Lin10,11; Lv, Luxian12,13
刊名SCHIZOPHRENIA RESEARCH
出版日期2019-08-01
卷号210页码:262-269
ISSN号0920-9964
关键词Schizophrenia Auditory verbal hallucination Perisylvian language pathways Diffusion tensor imaging Hyperconnectivity Multi-site
DOI10.1016/j.schres.2018.12.024
通讯作者Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要Auditory verbal hallucinations (AVH) are one of the cardinal symptoms of schizophrenia, and are proposed to be associatedwith altered integrity of the left perisylvian language pathways. There is considerable heterogeneity in the pattern of white matter abnormalities across previous studies. We investigated the white matter integrity of the perisylvian language pathways in schizophrenia patientswith AVH based on a relatively large sample dataset fromfour different sites. 113 schizophrenia patientswith AVH, 96 patientswithout AVH(nAVH), and 269 healthy controls (HC) underwent diffusion-weighted imaging. Between-group comparisonswere performed on the fractional anisotropy (FA) values of the anterior, posterior, and long segment fasciculi within the perisylvian language network. Analysis of covariance among the 3 groups revealed the long segment of the left perisylvian language pathways was significantly different in FA value. Post hoc analysis showed that compared with the HC group, the AVH group had significantly higher FA measurements in the left long segment. The nAVH group showed intermediate FA values for this segment compared to the AVH and HC group but did not differ significantly from either group. Furthermore, the prospective meta-analyses also revealed that FA value of the left long segment was significantly higher in the AVH group compared to the HC group. Our findings suggest the hyperconnectivity pattern of the left perisylvian language pathways in the presence of AVH in schizophrenia and support the self-monitoring of inner speech model. (C) 2018 Elsevier B.V. All rights reserved.
WOS关键词ARCUATE FASCICULUS ; FUNCTIONAL CONNECTIVITY ; INTEGRITY ; NETWORKS ; STIMULATION ; PLASTICITY ; MOTION
资助项目Zhejiang Provincial Natural Science Foundation of China[LQ19F030012] ; National Basic Research Program of China (973)[2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02030300] ; Natural Science Foundation of China[91132301] ; Natural Science Foundation of China[91432302]
WOS研究方向Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000479125500038
资助机构Zhejiang Provincial Natural Science Foundation of China ; National Basic Research Program of China (973) ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/27616]  
专题自动化研究所_脑网络组研究中心
通讯作者Jiang, Tianzi
作者单位1.Hangzhou Dianzi Univ, Coll Life Informat Sci & Instrument Engn, Hangzhou 310018, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Sichuan, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
9.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China
10.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Sangma,Liu, Bing,Wang, Jiaojian,et al. Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study[J]. SCHIZOPHRENIA RESEARCH,2019,210:262-269.
APA Xie, Sangma.,Liu, Bing.,Wang, Jiaojian.,Zhou, Yuan.,Cui, Yue.,...&Jiang, Tianzi.(2019).Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study.SCHIZOPHRENIA RESEARCH,210,262-269.
MLA Xie, Sangma,et al."Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study".SCHIZOPHRENIA RESEARCH 210(2019):262-269.

入库方式： OAI收割

来源：自动化研究所

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