The fusion landscape of hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Zhu, Chengpei1,2; Wu, Liangcai1,2; Lv, Yanling1,2,3; Guan, Jinxia1,2,3; Bai, Xue1,2; Lin, Jianzhen1,2; Liu, Tingting3; Yang, Xiaobo1,2; Robson, Simon C.4,5; Sang, Xinting1,2 |
| 刊名 | MOLECULAR ONCOLOGY
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 13期号:5页码:1214-1225 |
| 关键词 | biomarker gene fusion hepatocellular carcinoma recurrent fusion gene |
| ISSN号 | 1574-7891 |
| DOI | 10.1002/1878-0261.12479 |
| 通讯作者 | Sang, Xinting(SangXT@pumch.cn) ; Xue, Chenghai(chenghai.xue@myhealthgene.com) ; Zhao, Haitao(ZhaoHT@pumch.cn) |
| 英文摘要 | Most cases of hepatocellular carcinoma (HCC) are already advanced at the time of diagnosis, which limits treatment options. Challenges in early-stage diagnosis may be due to the genetic complexity of HCC. Gene fusion plays a critical function in tumorigenesis and cancer progression in multiple cancers, yet the identities of fusion genes as potential diagnostic markers in HCC have not been investigated. Here, we employed STAR-Fusion and identified 43 recurrent fusion events in our own and four public RNA-seq datasets. We identified 2354 different gene fusions in two hepatitis B virus (HBV)-HCC patients. Validation analysis against the four RNA-seq datasets revealed that only 1.8% (43/2354) were recurrent fusions. Comparison with the four fusion databases demonstrated that 19 recurrent fusions were not previously annotated to diseases and three were annotated as disease-related fusion events. Finally, we validated six of the novel fusion events, including RP11-476K15.1-CTD-2015H3.2, by RT-PCR and Sanger sequencing of 14 pairs of HBV-related HCC samples. In summary, our study provides new insights into gene fusions in HCC and may contribute to the development of anti-HCC therapy. |
| WOS关键词 | GENE FUSIONS ; RNA-SEQ ; CHIMERIC TRANSCRIPT ; IMATINIB MESYLATE ; CANCER ; IDENTIFICATION ; TRANSLOCATIONS ; HETEROGENEITY ; CHROMOSOME ; BIOMARKERS |
| 资助项目 | International Science and Technology Cooperation Projects[2016YFE0107100] ; International Science and Technology Cooperation Projects[2015DFA30650] ; CAMS Innovation Fund for Medical Science (CIFMS)[2017-I2M-4-003] ; Capital Special Research Project for Health Development[2014-2-4012] ; Beijing Natural Science Foundation[L172055] ; National Ten-thousand Talent Program ; Beijing Science and Technology Cooperation Special Award Subsidy Project |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000477090700016 |
| 出版者 | WILEY |
| 资助机构 | International Science and Technology Cooperation Projects ; CAMS Innovation Fund for Medical Science (CIFMS) ; Capital Special Research Project for Health Development ; Beijing Natural Science Foundation ; National Ten-thousand Talent Program ; Beijing Science and Technology Cooperation Special Award Subsidy Project |
| 源URL | [http://ir.ia.ac.cn/handle/173211/27787]  |
| 专题 | 自动化研究所_复杂系统管理与控制国家重点实验室 |
| 通讯作者 | Sang, Xinting; Xue, Chenghai; Zhao, Haitao |
| 作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100730, Peoples R China 3.My Hlth Gene Technol Co Ltd, Serv Ctr Tianjin Chentang Sci & Technol Commercia, Tianjin, Peoples R China 4.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Ctr Liver, Boston, MA 02115 USA 5.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Transplant Inst, Boston, MA 02115 USA 6.Chinese Acad Sci, Inst Automat, Joint Lab Large Scale Med Data Pattern Min & Appl, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Chengpei,Wu, Liangcai,Lv, Yanling,et al. The fusion landscape of hepatocellular carcinoma[J]. MOLECULAR ONCOLOGY,2019,13(5):1214-1225. |
| APA | Zhu, Chengpei.,Wu, Liangcai.,Lv, Yanling.,Guan, Jinxia.,Bai, Xue.,...&Zhao, Haitao.(2019).The fusion landscape of hepatocellular carcinoma.MOLECULAR ONCOLOGY,13(5),1214-1225. |
| MLA | Zhu, Chengpei,et al."The fusion landscape of hepatocellular carcinoma".MOLECULAR ONCOLOGY 13.5(2019):1214-1225. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。