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Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT

文献类型：期刊论文

作者Yang, Zehong2,3; Zhang, Xiang2,3; Fang, Mengjie4,5; Li, Guolin1,3; Duan, Xiaohui2,3; Mao, Jiaji2,3; Shen, Jun2,3
刊名AMERICAN JOURNAL OF ROENTGENOLOGY
出版日期2019-07-01
卷号213期号:1页码:W17-W25
关键词colorectal neoplasm diagnostic imaging lymphadenopathy MDCT
ISSN号0361-803X
DOI10.2214/AJR.18.20843
通讯作者Shen, Jun(shenjun@mail.sysu.edu.cn)
英文摘要OBJECTIVE. The purpose of this study was to investigate the performance of quantitative parameters derived from dual-energy CT (DECT) in the preoperative diagnosis of regional metastatic lymph nodes (LNs) in patients with colorectal cancer. SUBJECTS AND METHODS. Triphasic contrast-enhanced DECT was performed for 178 patients with colon or high rectal cancer. The morphologic criteria, short-axis diameter, and quantitative DECT parameters of the largest regional LN were measured and compared between pathologically metastatic and nonmetastatic LNs. Univariate and multivariable logistic regression analyses were used to determine the independent DECT parameters for predicting LN metastasis. Diagnostic performance measures were assessed by ROC curve analysis and compared by McNemar test. RESULTS. A total of 178 largest LNs (72 metastatic, 106 nonmetastatic) were identified in 178 patients. The best single DECT parameter for differentiation between metastatic and nonmetastatic LNs was normalized effective atomic number (Z(eff)) in the portal venous phase (AUC, 0.871; accuracy, 84.8%). These values were higher than those of morphologic criteria (AUC, 0.505-0.624; accuracy, 478-62.4%) and short-axis diameter (AUC, 0.647; accuracy, 66.3%) (p < 0.05). The diagnostic accuracy of combined normalized iodine concentration in the arterial phase and normalized effective atomic number in the portal venous phase was further improved to 871% (AUC, 0.916). CONCLUSION. Quantitative parameters derived from DECT can be used to improve preoperative diagnostic accuracy in evaluation for regional metastatic LNs in patients with colorectal cancer.
WOS关键词COLON-CANCER ; COMPUTED-TOMOGRAPHY ; IODINE CONCENTRATION ; ADJUVANT THERAPY ; F-18-FDG PET ; SPECTRAL CT ; ACCURACY ; ANGIOGENESIS ; METAANALYSIS
资助项目Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme ; National Natural Science Foundation of China[81571739] ; National Natural Science Foundation of China[81371607] ; Guangdong Natural Science Foundation[2014A030312018] ; Guangdong Natural Science Foundation[2017A030313777] ; National Basic Research Program of China[2015CB755500] ; Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital[J201403]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000472493900003
出版者AMER ROENTGEN RAY SOC
资助机构Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme ; National Natural Science Foundation of China ; Guangdong Natural Science Foundation ; National Basic Research Program of China ; Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital
源URL[http://ir.ia.ac.cn/handle/173211/27854]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Shen, Jun
作者单位1.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, 107 Yanjiang Rd W, Guangzhou 510120, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Sun Yet Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Key Lab Mol Imaging, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Zehong,Zhang, Xiang,Fang, Mengjie,et al. Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT[J]. AMERICAN JOURNAL OF ROENTGENOLOGY,2019,213(1):W17-W25.
APA Yang, Zehong.,Zhang, Xiang.,Fang, Mengjie.,Li, Guolin.,Duan, Xiaohui.,...&Shen, Jun.(2019).Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT.AMERICAN JOURNAL OF ROENTGENOLOGY,213(1),W17-W25.
MLA Yang, Zehong,et al."Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT".AMERICAN JOURNAL OF ROENTGENOLOGY 213.1(2019):W17-W25.

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来源：自动化研究所

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