FOXO Transcriptional Factors and Long-Term Living
文献类型：期刊论文
| 作者 | Murtaza, Ghulam2,3,4; Khan, Abida Kalsoom5; Rashid, Rehana5; Muneer, Saiqa6; Hasan, Syed Muhammad Farid1; Chen, Jianxin2 |
| 刊名 | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
 |
| 出版日期 | 2017 |
| 页码 | 8 |
| ISSN号 | 1942-0900 |
| DOI | 10.1155/2017/3494289 |
| 通讯作者 | Murtaza, Ghulam(gmdogar356@gmail.com) ; Chen, Jianxin(cjx@bucm.edu.cn) |
| 英文摘要 | Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity. |
| WOS关键词 | EMBRYONIC STEM-CELLS ; HUMAN LONGEVITY ; LIFE-SPAN ; CAENORHABDITIS-ELEGANS ; OXIDATIVE STRESS ; CALORIC RESTRICTION ; PROTEASOME ACTIVITY ; INSULIN-RESISTANCE ; EXTREME LONGEVITY ; SIGNALING PATHWAY |
| 资助项目 | National Natural Science Foundation of China[81522051] ; Beijing Nova Program[XX2013032] ; President's International Fellowship Initiative (PIFI), Chinese Academy of Sciences (CAS), China[2016PT009] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000407889200001 |
| 出版者 | HINDAWI LTD |
| 资助机构 | National Natural Science Foundation of China ; Beijing Nova Program ; President's International Fellowship Initiative (PIFI), Chinese Academy of Sciences (CAS), China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/28011]  |
| 专题 | 离退休人员 |
| 通讯作者 | Murtaza, Ghulam; Chen, Jianxin |
| 作者单位 | 1.Univ Karachi, Fac Pharm & Pharmaceut Sci, Dept Pharmaceut, Karachi, Pakistan 2.Beijing Univ Chinese Med, Beisanhuan East Rd, Beijing 100029, Peoples R China 3.COMSATS Inst Informat Technol, Dept Pharm, Abbottabad, Pakistan 4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 5.COMSATS Inst Informat Technol, Dept Chem, Abbottabad, Pakistan 6.Univ Lahore, Dept Pharm, Lahore, Pakistan |
| 推荐引用方式 GB/T 7714 | Murtaza, Ghulam,Khan, Abida Kalsoom,Rashid, Rehana,et al. FOXO Transcriptional Factors and Long-Term Living[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2017:8. |
| APA | Murtaza, Ghulam,Khan, Abida Kalsoom,Rashid, Rehana,Muneer, Saiqa,Hasan, Syed Muhammad Farid,&Chen, Jianxin.(2017).FOXO Transcriptional Factors and Long-Term Living.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,8. |
| MLA | Murtaza, Ghulam,et al."FOXO Transcriptional Factors and Long-Term Living".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017):8. |
入库方式： OAI收割
来源：自动化研究所
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