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Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers

文献类型：期刊论文

作者Yuan, Kai1,2,3,4,5; Zhao, Meng1,3; Yu, Dahua3; Manza, Peter2; Volkow, Nora D.2,6; Wang, Gene-Jack2; Tian, Jie1,3,7
刊名NEUROPSYCHOPHARMACOLOGY
出版日期2018-11-01
卷号43期号:12页码:2452-2458
ISSN号0893-133X
DOI10.1038/s41386-018-0182-x
通讯作者Yuan, Kai(kyuan@xidian.edu.cn)
英文摘要Striatal circuit dysfunction is implicated in smoking behaviors and lapses during abstinence attempts. However, little is known about whether the structural connectivity of striatal tracts can be used to predict abstinence-induced craving and lapses. The tract strengths of striatal circuits were compared in 53 male nicotine-dependent cigarette smokers and 58 matched nonsmokers, using seed-based classification by diffusion tensor imaging (DTI) probabilistic tractography with 10 a priori target masks. A 12-h abstinence procedure was then employed, after which 31 individuals abstained and 22 lapsed. Linear regression and binary logistic regression was conducted to test whether the tract strength of frontostriatal circuits was associated with craving changes in abstainers and predicted lapse in smokers. Compared with nonsmokers, in the left hemisphere, smokers showed weaker tract strength in striatum-medial orbitofrontal cortex (mOFC), striatum-ventral lateral prefrontal cortex (vlPFC), striatum-inferior frontal gyrus (IFG) and striatum-posterior cingulate cortex (PCC) (Bonferroni corrected, p < 0.05/20 = 0.0025). In abstainers, the abstinence-induced increases in craving were associated with the tract strength of the left striatum-mOFC and striatum-vlPFC. The tract strength of left striatum-dorsolateral PFC (dlPFC) predicted lapse in smokers with an accuracy of 68.3%. These results provide system-level insights into the weaker tract strength of frontostriatal circuits in male smokers and their potential roles as neuroimaging markers for abstinence-induced craving and risk of lapse. Future studies in female smokers are needed to determine if this generalizes across genders.
WOS关键词STATE FUNCTIONAL CONNECTIVITY ; CIGARETTE-SMOKING ; PREFRONTAL CORTEX ; RESTING-STATE ; COGNITIVE CONTROL ; DOPAMINE RELEASE ; FRONTOSTRIATAL CONNECTIVITY ; SEX-DIFFERENCES ; CUE REACTIVITY ; YOUNG SMOKERS
资助项目National Natural Science Foundation of China[81871426] ; National Natural Science Foundation of China[81871430] ; National Natural Science Foundation of China[81571751] ; National Natural Science Foundation of China[81571753] ; National Natural Science Foundation of China[61771266] ; National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[81701780] ; Fundamental Research Funds for the Central Universities[JB151204] ; program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region[NJYT-17-B11] ; Natural Science Foundation of Inner Mongolia[2017MS(LH) 0814] ; program of Science and Technology in Universities of Inner Mongolia Autonomous Region[NJZY17262] ; Innovation Fund Project of Inner Mongolia University of Science and Technology[2015QNGG03] ; National Natural Science Foundation of Shaanxi Province[2018JM7075] ; US National Institutes of Health[Y1AA3009]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000446868600017
资助机构National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region ; Natural Science Foundation of Inner Mongolia ; program of Science and Technology in Universities of Inner Mongolia Autonomous Region ; Innovation Fund Project of Inner Mongolia University of Science and Technology ; National Natural Science Foundation of Shaanxi Province ; US National Institutes of Health
源URL[http://ir.ia.ac.cn/handle/173211/28124]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Yuan, Kai
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.NIAAA, NIH, Bethesda, MD 20892 USA
3.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
5.Guangxi Normal Univ, Guangxi Key Lab Multisource Informat Min & Secur, Guilin 541001, Peoples R China
6.NIDA, NIH, Bethesda, MD 20892 USA
7.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Kai,Zhao, Meng,Yu, Dahua,et al. Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers[J]. NEUROPSYCHOPHARMACOLOGY,2018,43(12):2452-2458.
APA Yuan, Kai.,Zhao, Meng.,Yu, Dahua.,Manza, Peter.,Volkow, Nora D..,...&Tian, Jie.(2018).Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers.NEUROPSYCHOPHARMACOLOGY,43(12),2452-2458.
MLA Yuan, Kai,et al."Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers".NEUROPSYCHOPHARMACOLOGY 43.12(2018):2452-2458.

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