Metal-organic framework-coated magnetite nanoparticles for synergistic magnetic hyperthermia and chemotherapy with pH-triggered drug release
文献类型：期刊论文
| 作者 | Chen, Jiajie; Liu, Jiaxing; Hu, Yaping; Tian, Zhengfang; Zhu, Yufang |
| 刊名 | SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
 |
| 出版日期 | 2019-12-31 |
| 卷号 | 20期号:1页码:1043 |
| ISSN号 | 1468-6996 |
| 关键词 | Multifunctional nanoparticles metal-organic frameworks magnetic hyperthermia chemotherapy synergistic effect |
| DOI | 10.1080/14686996.2019.1682467 |
| 文献子类 | Article |
| 英文摘要 | In nanoplatform-based tumor treatment, combining chemotherapy with hyperthermia therapy is an interesting strategy to achieve enhanced therapeutic efficacy with low dose of delivery drugs. Compared to photothermal therapy, magnetic hyperthermia has few restrictions on penetrating tissue by an alternating magnetic field, and thereby could cure various solid tumors, even deep-tissue ones. In this work, we proposed to construct magnetic nanocomposites (Fe3O4@PDA@ZIF-90) by the external growth of metal-organic framework ZIF-90 on polydopamine (PDA)-coated Fe3O4 nanoparticles for synergistic magnetic hyperthermia and chemotherapy. In such multifunctional platform, Fe3O4 nanoparticle was utilized as a magnetic heating seed, PDA layer acted as an inducer for the growth of ZIF-90 shell and porous ZIF-90 shell served as drug nanocarrier to load doxorubicin (DOX). The well-defined Fe3O4@PDA@ZIF-90 core-shell nanoparticles were displayed with an average size of ca. 200?nm and possessed the abilities to load high capacity of DOX as well as trigger drug release in a pH-responsive way. Furthermore, the Fe3O4@PDA@ZIF-90 nanoparticles can raise the local temperature to meet hyperthermia condition under an alternating magnetic field owing to the magnetocaloric effect of Fe3O4 cores. In the in vitro experiments, the Fe3O4@PDA@ZIF-90 nanoparticles showed a negligible cytotoxicity to Hela cells. More significantly, after cellular internalization, the DOX-loaded Fe3O4@PDA@ZIF-90 nanoparticles exhibited distinctively synergistic effect to kill tumor cells with higher efficacy compared to chemotherapy or magnetic hyperthermia alone, presenting a great potential for efficient tumor therapy. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26695]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Jiajie,Liu, Jiaxing,Hu, Yaping,et al. Metal-organic framework-coated magnetite nanoparticles for synergistic magnetic hyperthermia and chemotherapy with pH-triggered drug release[J]. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS,2019,20(1):1043. |
| APA | Chen, Jiajie,Liu, Jiaxing,Hu, Yaping,Tian, Zhengfang,&Zhu, Yufang.(2019).Metal-organic framework-coated magnetite nanoparticles for synergistic magnetic hyperthermia and chemotherapy with pH-triggered drug release.SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS,20(1),1043. |
| MLA | Chen, Jiajie,et al."Metal-organic framework-coated magnetite nanoparticles for synergistic magnetic hyperthermia and chemotherapy with pH-triggered drug release".SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS 20.1(2019):1043. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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