Codoping Enhanced Radioluminescence of Nanoscintillators for X-ray-Activated Synergistic Cancer Therapy and Prognosis Using Metabolomics
文献类型：期刊论文
| 作者 | Ahmad, Farooq; Wang, Xiaoyan; Jiang, Zhao; Yu, Xujiang; Liu, Xinyi; Mao, Rihua; Chen, Xiaoyuan; Li, Wanwan |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 13期号:9页码:10419 |
| 关键词 | codoped nanoscintillators imaging radiotherapy X-ray inducible photodynamic therapy metabolomics |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b04213 |
| 文献子类 | Article |
| 英文摘要 | Radio- and photodynamic therapies are the first line of cancer treatments but suffer from poor light penetration and less radiation accumulation in soft tissues with high radiation toxicity. Therefore, a multifunctional nanoplatform with diagnosis-assisted synergistic radio- and photodynamic therapy and tools facilitating early prognosis Rose Further, integrating cancer therapy with untargeted are urgently needed to fight the war against cancer. Bengal metabolomic analysis would collectively offer clinical pertinence through facilitating early diagnosis and prognosis. Here, we enriched scintillation of CeF3 nanoparticles (NPs) through codoping Tb3+ and Gd3+ (CeF3:Gd3+,Tb3+) for viable clinical approach in the treatment of deep-seated tumors. The codoped CeF3:Gd3+,Tb3+ scintillating theranostic NPs were then coated with mesoporous silica, followed by loading with rose bengal (CGTS-RB) for later computed tomography (CT)- and magnetic resonance image (MRI)-guided X-ray stimulated synergistic radio- and photodynamic therapy (RT+XPDT) using low-dose, one-time X-ray irradiation. The results corroborated an efficient tumor regression with synergistic RT+XPDT relative to single RT. Global untargeted metabolome shifts highlighted the mechanism behind this efficient tumor regression using RT, and synergistic RT+XPDT treatment is due to the starvation of nonessential amino acids involved in protein and DNA synthesis and energy regulation pathways necessary for growth and progression. Our study also concluded that tumor and serum metabolites shift during disease progression and regression and serve as robust biomarkers for early assessment of disease state and prognosis. From our results, we propose that codoping is an effective and extendable technique to other materials for gaining high optical yield and multifunctionality and for use in diagnostic and therapeutic applications. Critically, the integration of multifunctional theranostic nanomedicines with metabolomics has excellent potential for the discovery of early metabolic biomarkers to aid in better clinical disease diagnosis and prognosis. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26863]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Ahmad, Farooq,Wang, Xiaoyan,Jiang, Zhao,et al. Codoping Enhanced Radioluminescence of Nanoscintillators for X-ray-Activated Synergistic Cancer Therapy and Prognosis Using Metabolomics[J]. ACS NANO,2019,13(9):10419. |
| APA | Ahmad, Farooq.,Wang, Xiaoyan.,Jiang, Zhao.,Yu, Xujiang.,Liu, Xinyi.,...&Li, Wanwan.(2019).Codoping Enhanced Radioluminescence of Nanoscintillators for X-ray-Activated Synergistic Cancer Therapy and Prognosis Using Metabolomics.ACS NANO,13(9),10419. |
| MLA | Ahmad, Farooq,et al."Codoping Enhanced Radioluminescence of Nanoscintillators for X-ray-Activated Synergistic Cancer Therapy and Prognosis Using Metabolomics".ACS NANO 13.9(2019):10419. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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