Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection
文献类型：期刊论文
| 作者 | Ni, Dalong; Wei, Hao; Chen, Weiyu; Bao, Qunqun; Rosenkrans, Zachary T.; Barnhart, Todd E.; Ferreira, Carolina A.; Wang, Yanpu; Yao, Heliang; Sun, Tuanwei |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 31期号:40 |
| 关键词 | acute livery injury ceria nanoparticles hepatic ischemia-reperfusion injury nano-antixoidants reactive oxygen species |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201902956 |
| 文献子类 | Article |
| 英文摘要 | The mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a "blackbox" by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano-antioxidants with preferential liver uptake to directly prevent hepatic ischemia-reperfusion injury (IRI), which is a reactive oxygen species (ROS)-related disease. Ceria nanoparticles (NPs) are selected as a representative nano-antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro-inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano-antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26902]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Ni, Dalong,Wei, Hao,Chen, Weiyu,et al. Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection[J]. ADVANCED MATERIALS,2019,31(40). |
| APA | Ni, Dalong.,Wei, Hao.,Chen, Weiyu.,Bao, Qunqun.,Rosenkrans, Zachary T..,...&Cai, Weibo.(2019).Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection.ADVANCED MATERIALS,31(40). |
| MLA | Ni, Dalong,et al."Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection".ADVANCED MATERIALS 31.40(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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