Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions
文献类型：期刊论文
| 作者 | Huang, Yongping; Shao, Yiran; Zhu, Yingchun |
| 刊名 | JOURNAL OF BIOMATERIALS APPLICATIONS
 |
| 出版日期 | 2019-11-01 |
| 卷号 | 34期号:5页码:728 |
| 关键词 | Percarbamide nanomedicine free radical chain reactions reactive oxygen species soft-X-Ray cancer therapy |
| ISSN号 | 0885-3282 |
| DOI | 10.1177/0885328219868851 |
| 文献子类 | Article |
| 英文摘要 | Free radicals are toxic agents known to induce cellular oxidative damage, and reactive oxygen species plays a key role in cancer therapy. Herein, we develop an efficient delivery nanomedicine for controlled free radical generation by loading innocuous percarbamide in chitosan-coated hollow mesoporous silica nanoparticles (PCA@HMSNs-CTS). Reactive oxygen species was generated continuously and kept at a high level during the sustained release process of hydrogen peroxide from PCA@HMSNs-CTS. The evidences for mechanism revealed an autocatalytic free radical chain reactions initiated by a short time soft-X-Ray. The reactive oxygen species intensity in solutions after initiation is 5.8-fold higher than that without soft-X-Ray initiation following with the decomposition of hyperoxides and generation of oxygen. PCA@HMSNs-CTS exhibit a pH-responsive reactive oxygen species release, and the reactive oxygen species exhibit a significant high level in cancer cells which efficiently decrease the cell viability. This work explores the radical generation strategy of percarbamide nanomedicine and is expected to present a new avenue to efficient nanomedicine for cancer therapy. |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26912]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Huang, Yongping,Shao, Yiran,Zhu, Yingchun. Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2019,34(5):728. |
| APA | Huang, Yongping,Shao, Yiran,&Zhu, Yingchun.(2019).Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions.JOURNAL OF BIOMATERIALS APPLICATIONS,34(5),728. |
| MLA | Huang, Yongping,et al."Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions".JOURNAL OF BIOMATERIALS APPLICATIONS 34.5(2019):728. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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