Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Meng; Song, Ruixue; Liu, Yanyan; Yi, Zhigao; Meng, Xianfu; Zhang, Jiawen; Tang, Zhongmin; Yao, Zhenwei; Liu, Yang; Liu, Xiaogang |
| 刊名 | CHEM
 |
| 出版日期 | 2019-08-08 |
| 卷号 | 5期号:8页码:2171 |
| ISSN号 | 2451-9294 |
| DOI | 10.1016/j.chempr.2019.06.003 |
| 文献子类 | Article |
| 英文摘要 | Calcium overload, characterized by an abnormal cytoplasm accumulation of free calcium ions (Ca2+), is a widely recognized cause of damage in numerous cell types and even of cell death. This undesirable destructive process can become a new tool applicable to cancer treatment. Herein, on the basis of the unique biological effect of Ca2+ we demonstrate a highly efficient strategy for tumor therapy by utilizing pH-sensitive sodium-hyaluronate-modified calcium peroxide nanoparticles (SH-CaO2 NPs). These NPs create an artificial calcium overloading stress in tumor cells, which is responsible for cell death. Notably, the killing effect is not limited to tumor types or hypoxic cells, and normal cells are more tolerant of the adverse influence of NPs than tumor cells. The Ca2+ enrichment also increases the likelihood of tumor calcification, which could contribute to in vivo tumor inhibition and facilitate medical imaging to monitor the treatment efficacy. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26914]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Meng,Song, Ruixue,Liu, Yanyan,et al. Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles[J]. CHEM,2019,5(8):2171. |
| APA | Zhang, Meng.,Song, Ruixue.,Liu, Yanyan.,Yi, Zhigao.,Meng, Xianfu.,...&Bu, Wenbo.(2019).Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.CHEM,5(8),2171. |
| MLA | Zhang, Meng,et al."Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles".CHEM 5.8(2019):2171. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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