Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings
文献类型：期刊论文
| 作者 | Cui, Mengkui; Wang, Xinyu; An, Bolin; Zhang, Chen; Gui, Xinrui; Li, Ke; Li, Yingfeng; Ge, Peng; Zhang, Junhu; Liu, Cong |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 5期号:8 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.aax3155 |
| 文献子类 | Article |
| 英文摘要 | Many biological materials form via liquid-liquid phase separation (LLPS), followed by maturation into a solid-like state. Here, using a biologically inspired assembly mechanism designed to recapitulate these sequential assemblies, we develop ultrastrong underwater adhesives made from engineered proteins containing mammalian low-complexity (LC) domains. We show that LC domain-mediated LLPS and maturation substantially promotes the wetting, adsorption, priming, and formation of dense, uniform amyloid nanofiber coatings on diverse surfaces (e.g., Teflon), and even penetrating difficult-to-access locations such as the interiors of microfluidic devices. Notably, these coatings can be deposited on substrates over a broad range of pH values (3 to 11) and salt concentrations (up to 1 M NaCl) and exhibit strong underwater adhesion performance. Beyond demonstrating the utility of mammalian LC domains for driving LLPS in soft materials applications, our study illustrates a powerful example of how combining LLPS with subsequent maturation steps can be harnessed for engineering protein-based materials. |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26928]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Cui, Mengkui,Wang, Xinyu,An, Bolin,et al. Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings[J]. SCIENCE ADVANCES,2019,5(8). |
| APA | Cui, Mengkui.,Wang, Xinyu.,An, Bolin.,Zhang, Chen.,Gui, Xinrui.,...&Zhong, Chao.(2019).Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings.SCIENCE ADVANCES,5(8). |
| MLA | Cui, Mengkui,et al."Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings".SCIENCE ADVANCES 5.8(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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