Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy
文献类型：期刊论文
| 作者 | Liang, Ruijie; Chen, Yu; Huo, Minfeng; Zhang, Jun; Li, Yongsheng |
| 刊名 | NANOSCALE HORIZONS
 |
| 出版日期 | 2019-07-01 |
| 卷号 | 4期号:4页码:890 |
| ISSN号 | 2055-6756 |
| DOI | 10.1039/c9nh00008a |
| 文献子类 | Article |
| 英文摘要 | The tumor microenvironment (TME) provides intriguing features/indications for rational design of diverse therapeutic protocols with high tumor specificity and therapeutic efficacy. In this work, we report the introduction of the sequential catalytic concept into theranostic nanomedicine for cancer-specific therapy, which has been achieved by the construction of glucose oxidase (GOD) and Mitomycin C (MMC) co-loaded superparamagnetic iron oxide nanoparticles (designated as SMG nanocatalysts). Based on the large amounts of glucose in tumors, the GOD component in SMG catalyzes glucose to convert into hydrogen peroxide (H2O2) and gluconic acid with the simultaneous consumption of oxygen. The post-produced H2O2 is further catalyzed by iron oxide in SMG to produce large amounts of highly toxic hydroxyl radicals for cancer therapy, and the generated gluconic acid enhances such a Fenton-based catalytic reaction. On the other hand, the loaded MMC drug is activated because of the consumption of oxygen and enhanced hypoxia in tumors, causing high chemotherapeutic efficacy. Based on the high synergistic chemodrug and chemodynamic therapeutic efficacy in combating cancer, cancer cells are efficiently killed and tumor growth is thus significantly suppressed. This work paves a new way for cancer therapy by taking into account the full features and advantages of the TME and the physiochemical properties of the chosen nanocatalysts, which also links nanocatalytic science and nanomedicine for proposing new efficient tumor-therapeutic modalities. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27003]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Liang, Ruijie,Chen, Yu,Huo, Minfeng,et al. Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy[J]. NANOSCALE HORIZONS,2019,4(4):890. |
| APA | Liang, Ruijie,Chen, Yu,Huo, Minfeng,Zhang, Jun,&Li, Yongsheng.(2019).Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy.NANOSCALE HORIZONS,4(4),890. |
| MLA | Liang, Ruijie,et al."Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy".NANOSCALE HORIZONS 4.4(2019):890. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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