Minocycline hydrochloride loaded graphene oxide enables enhanced osteogenic activity in the presence of Gram-positive bacteria, Staphylococcus aureus
文献类型：期刊论文
| 作者 | Qiu, Jiajun; Qian, Wenhao; Zhang, Jinkai; Chen, Dafu; Yeung, Kelvin W. K.; Liu, Xuanyong |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2019-06-14 |
| 卷号 | 7期号:22页码:3590 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c9tb00405j |
| 文献子类 | Article |
| 英文摘要 | Implant failures still happen because of bacterial infections and inferior osteogenic properties. Graphene oxide (GO) could induce osteogenic differentiation as well as exhibit superior antibacterial activity which may provide an answer for this issue. In this work, GO films loaded with minocycline hydrochloride (MH) were fabricated on titanium implant surfaces, and the antibacterial activity and osteogenic properties were studied in the presence of S. aureus and rat bone mesenchymal stem cells (rBMSCs) in in vitro and in vivo environments, respectively. The results indicated that the MH loaded GO films on titanium surfaces (MH&GO@Ti) exhibited enhanced osteogenic activity in vitro with improved alkaline phosphatase (ALP) activity and enhanced osteogenic related gene expressions including ALP, collagen-I, osteocalcin, and osteopontin. The in vitro results of the co-culture of rBMSCs and S. aureus indicated that the rBMSCs grew well on the MH&GO@Ti sample with a higher coverage of cells and the bacteria were almost unobservable on the surface. In the in vivo experiments, the MH&GO@Ti exhibited excellent antibacterial and osteogenic activities in the presence of bacteria. No inflammatory cells for example neutrophils were found and superior bone-implant integration was obtained. This study offers a new proposal for the clinical application of drug-loaded graphene coating. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27051]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Qiu, Jiajun,Qian, Wenhao,Zhang, Jinkai,et al. Minocycline hydrochloride loaded graphene oxide enables enhanced osteogenic activity in the presence of Gram-positive bacteria, Staphylococcus aureus[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(22):3590. |
| APA | Qiu, Jiajun,Qian, Wenhao,Zhang, Jinkai,Chen, Dafu,Yeung, Kelvin W. K.,&Liu, Xuanyong.(2019).Minocycline hydrochloride loaded graphene oxide enables enhanced osteogenic activity in the presence of Gram-positive bacteria, Staphylococcus aureus.JOURNAL OF MATERIALS CHEMISTRY B,7(22),3590. |
| MLA | Qiu, Jiajun,et al."Minocycline hydrochloride loaded graphene oxide enables enhanced osteogenic activity in the presence of Gram-positive bacteria, Staphylococcus aureus".JOURNAL OF MATERIALS CHEMISTRY B 7.22(2019):3590. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。