Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy
文献类型：期刊论文
| 作者 | Gao, Shanshan; Lu, Xiangyu; Zhu, Piao; Lin, Han; Yu, Luodan; Yao, Heliang; Wei, Chenyang; Chen, Yu; Shi, Jianlin |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2019-06-14 |
| 卷号 | 7期号:22页码:3599 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c9tb00525k |
| 文献子类 | Article |
| 英文摘要 | The emerging nanocatalytic tumor therapy such as chemodynamic therapy (CDT) converts less harmful hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (OH) via metal ion-mediated catalytic Fenton chemistry, which has motivated extensive research interest due to the high specificity of the nanocatalytic reactions to the tumor microenvironment (TME) and minimized side effects. However, traditional CDT substantially suffers from the insufficiency of intratumoral H2O2 for inducing a satisfactory therapeutic efficacy. In this work, we report on a photothermally-promoted Fenton reaction triggered by self-supplied H2O2, based on the constructed two-dimensional (2D) multifunctional therapeutic Nb2C-IO-CaO2 nanoreactors with enhanced therapeutic efficacy and therapeutic biosafety. These Nb2C-IO-CaO2 nanoreactors employ calcium peroxide (CaO2) as a potent H2O2 supplier to sustain the iron oxide (IO) nanoparticle-mediated catalytic Fenton reaction, and to liberate highly toxic OH for inducing tumor-cell apoptosis. Meanwhile, the intratumoral OH production was further promoted by the photothermal effect of the Nb2C-IO-CaO2 nanoreactors under near infrared irradiation at the second biowindow. Extensive in vitro and in vivo evaluations have demonstrated significantly enhanced reactive oxygen species (ROS) production and an outstanding photothermal effect based on these Nb2C-IO-CaO2 nanoreactors, which synergistically lead to elevated therapeutic efficacy. Therefore, this work not only exhibits a promising prospect for reforming the TME to achieve enhanced Fenton reactivity for CDT by elaborately designed nanomaterials with multifunctionality, but also provides novel efficient cancer-therapeutic modalities with simultaneous high therapeutic efficacy and low side effects. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27052]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Gao, Shanshan,Lu, Xiangyu,Zhu, Piao,et al. Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(22):3599. |
| APA | Gao, Shanshan.,Lu, Xiangyu.,Zhu, Piao.,Lin, Han.,Yu, Luodan.,...&Shi, Jianlin.(2019).Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy.JOURNAL OF MATERIALS CHEMISTRY B,7(22),3599. |
| MLA | Gao, Shanshan,et al."Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy".JOURNAL OF MATERIALS CHEMISTRY B 7.22(2019):3599. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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