Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f
文献类型：期刊论文
| 作者 | Zhang, Meng; Shen, Bo; Song, Ruixue; Wang, Han; Lv, Bin; Meng, Xianfu; Liu, Yang; Liu, Yanyan; Zheng, Xiangpeng; Su, Weiwei |
| 刊名 | MATERIALS HORIZONS
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 6期号:5页码:1034 |
| ISSN号 | 2051-6347 |
| DOI | 10.1039/c8mh01554f |
| 文献子类 | Article |
| 英文摘要 | In high-Z element enhanced radiotherapy strategies, the clinical potential of metal-based nanocomposites is always reduced by the serious side effects of leaked heavy metal ions. In this study, we demonstrate a novel anticancer strategy to realize controllable cytotoxicity of metal elements with the aid of high-energy radiation, based on a design of chelator-modified barium peroxide nanoparticles (GL-BaO2 NPs). Free Ba2+ is a potassium channel inhibitor that inhibits cell proliferation. The chelator modification can strongly bind leaked free Ba2+, thus reducing its unwanted side effects in normal tissues. However, under X-ray radiation in tumor regions, the produced hydroxyl radicals will break the chemical structures of chelators. Consequently, the released Ba2+ can access the membrane without a barrier and contribute to tumor treatment. More importantly, the sensitization of Ba in the lattice of barium peroxide will directly transform peroxide groups into reactive hydroxyl radicals, which further guarantees the decomposition of chelators as well as the efficient killing of cells. This strategy, which we termed ion interference therapy, demonstrates a universal paradigm by employing the biological effects of metal ions in tumor treatment, revealing its industrial potential for radiotherapy enhancement. |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27068]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Meng,Shen, Bo,Song, Ruixue,et al. Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f[J]. MATERIALS HORIZONS,2019,6(5):1034. |
| APA | Zhang, Meng.,Shen, Bo.,Song, Ruixue.,Wang, Han.,Lv, Bin.,...&Bu, Wenbo.(2019).Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f.MATERIALS HORIZONS,6(5),1034. |
| MLA | Zhang, Meng,et al."Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f".MATERIALS HORIZONS 6.5(2019):1034. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。