Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging
文献类型：期刊论文
| 作者 | Ren, Xiangyi; Huo, Minfeng; Wang, Mengmeng; Lin, Han; Zhang, Xuxia; Yin, Jun; Chen, Yu; Chen, Honghong |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 13期号:6页码:6438 |
| 关键词 | Nb2C MXenes radiation protection free radical scavenger superoxide dismutase hematopoiesis |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b09327 |
| 文献子类 | Article |
| 英文摘要 | Ionizing radiation (IR) has been extensively used in industry and radiotherapy, but IR exposure from nuclear or radiological accidents often causes serious health effects in an exposed individual, and its application in radiotherapy inevitably brings undesirable damage to normal tissues. In this work, we have developed ultrathin two-dimensional (2D) niobium carbide (Nb2C) MXene as a radioprotectant and explored its application in scavenging free radicals against IR. The 2D Nb2C MXene features intriguing antioxidant properties in effectively eliminating hydrogen peroxide (H2O2), hydroxyl radicals ((OH)-O-center dot), and superoxide radicals (O-2(center dot-)). Pretreatment with biocompatible polyvinylpyrrolidone (PVP)-functionalized Nb2C nanosheets (Nb2C-PVP NSs) significantly reduces IR-induced production of reactive oxygen species (ROS), resulting in enhanced cell viability in vitro. A single intravenous injection of Nb2C-PVP significantly enhances the survival rate of 5 and 6.5 Gy irradiated mice to 100% and 81.25%, respectively, and significantly increases bone marrow mononuclear cells after IR. Critically, Nb2C-PVP reverses the damage of the hematopoietic system in irradiated mice. Single administration of Nb2C-PVP significantly increases superoxide dismutase (SOD) activities, decreases malondialdehyde levels, and thereby reduces IR-induced pathological damage in the testis, small intestine, lung, and liver of 5 Gy irradiated mice. Importantly, Nb2C-PVP is almost completely eliminated from the mouse body on day 14 post treatment, and no obvious toxicities are observed during the 30-day post treatment period. Our study pioneers the application of 2D MXenes with intrinsic radioprotective nature in vivo. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27070]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Ren, Xiangyi,Huo, Minfeng,Wang, Mengmeng,et al. Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging[J]. ACS NANO,2019,13(6):6438. |
| APA | Ren, Xiangyi.,Huo, Minfeng.,Wang, Mengmeng.,Lin, Han.,Zhang, Xuxia.,...&Chen, Honghong.(2019).Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging.ACS NANO,13(6),6438. |
| MLA | Ren, Xiangyi,et al."Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging".ACS NANO 13.6(2019):6438. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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