Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages
文献类型：期刊论文
| 作者 | Chen, Lan; Wang, Donghui; Peng, Feng; Qiu, Jiajun; Ouyang, Liping; Qjao, Yuqin; Liu, Xuanyong |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 19期号:6页码:3480 |
| 关键词 | surface elastic modulus macrophage polarization immune response implants molecular mechanism |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.9b00237 |
| 文献子类 | Article |
| 英文摘要 | A proper immune response is key for the successful implantation of biomaterials, and designing and fabricating biomaterials to regulate immune responses is the future trend. In this work, three different nanostructures were constructed on the surface of titanium using a hydrothermal method, and through a series of in vitro and in vivo experiments, we found that the aspect ratio of nanostructures can affect the elastic modulus of a material surface and further regulate immune cell behaviors. This work demonstrates that nanostructures with a higher aspect ratio can endow a material surface with a lower elastic modulus, which was confirmed by experiments and theoretical analyses. The deflection of nanostructures under the cell adsorption force is a substantial factor in stretching macrophages to enhance cell adhesion and spreading, further inducing macrophage polarization toward the M1 phenotype and leading to intense immune responses. In contrast, a nanostructure with a lower aspect ratio on a material surface leads to a higher surface elastic modulus, making deflection of the material difficult and creating a surface that is not conducive to macrophage adhesion and spreading, thus reducing the immune response. Moreover, molecular biology experiments indicated that regulation of the immune response by the elastic modulus is primarily related to the NF-kappa B signaling pathway. These findings suggest that the immune response can be regulated by constructing nanostructural surfaces with the proper elastic modulus through their influence on cell adhesion and spreading, which provides new insights into the surface design of biomaterials. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27072]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Lan,Wang, Donghui,Peng, Feng,et al. Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages[J]. NANO LETTERS,2019,19(6):3480. |
| APA | Chen, Lan.,Wang, Donghui.,Peng, Feng.,Qiu, Jiajun.,Ouyang, Liping.,...&Liu, Xuanyong.(2019).Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages.NANO LETTERS,19(6),3480. |
| MLA | Chen, Lan,et al."Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages".NANO LETTERS 19.6(2019):3480. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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