On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics
文献类型：期刊论文
| 作者 | Liu, Tianzhi; Wan, Qian; Luo, Yu; Chen, Mengjie; Zou, Chao; Ma, Ming; Liu, Xin; Chen, Hangrong |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2019-05-08 |
| 卷号 | 11期号:18页码:16285 |
| 关键词 | detachable nanotheranostics hybrid structure magnetic resonance imaging magnetic resonance thermometry high-intensity focused ultrasound |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.9b02062 |
| 文献子类 | Article |
| 英文摘要 | Engineering multiple theranostic modalities into a single nanoscale entity holds great potential to rejuvenate cancer treatments; however, enabling the sophisticated spatiotemporal control of each component for maximizing theranostic improvement and minimizing side effects concurrently remains a challenge. Herein, an intelligent detachable "nanorocket" is developed to sequentially manipulate and optimize multitheranostic processes for magnetic resonance-assisted ultrasound-drug combined therapy (MR-HIFU-Drug). The "nanorocket" is constructed by integrating multicomponent (MnCO3, doxorubicin, silica) on the pH-sensitive CaCO3 nanoparticles step by step via cation exchange and controlled heterogeneous nucleation, in which doxorubicin is encapsulated in both carbonates and silica component. The "nanorocket" can initiate sequential detachment in the acidic tumor microenvironment. Specifically, carbonates decompose instantly, releasing Mn2+ as the MR contrast agent and leaving hollow silica nanostructure behind as the HIFU synergistic agent. Consequently, burst release of drug is also triggered, further triggering the degradation of silica, which in turn regulates the slow release of drug from the silica matrix. Thus, efficient tumor inhibition is achieved by enhanced HIFU ablation and biphase release of doxorubicin with a stepwise clearance of Mn and Si. This work establishes a system for the systematic spatiotemporal dispatch of diverse theranostic components for the balance of efficacy and safety in cancer theranostics. |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27121]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Tianzhi,Wan, Qian,Luo, Yu,et al. On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(18):16285. |
| APA | Liu, Tianzhi.,Wan, Qian.,Luo, Yu.,Chen, Mengjie.,Zou, Chao.,...&Chen, Hangrong.(2019).On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,11(18),16285. |
| MLA | Liu, Tianzhi,et al."On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 11.18(2019):16285. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。