Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
文献类型：期刊论文
| 作者 | Yue, Wenwen; Chen, Liang; Yu, Luodan; Zhou, Bangguo; Yin, Haohao; Ren, Weiwei; Liu, Chang; Guo, Lehang; Zhang, Yifeng; Sun, Liping |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2019-05-02 |
| 卷号 | 10 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-09760-3 |
| 文献子类 | Article |
| 英文摘要 | Combined checkpoint blockade (e.g., PD1/PD-L1) with traditional clinical therapies can be hampered by side effects and low tumour-therapeutic outcome, hindering broad clinical translation. Here we report a combined tumour-therapeutic modality based on integrating nanosonosensitizers-augmented noninvasive sonodynamic therapy (SDT) with checkpoint-blockade immunotherapy. All components of the nanosonosensitizers (HMME/R837@Lip) are clinically approved, wherein liposomes act as carriers to co-encapsulate sonosensitizers (hematoporphyrin monomethyl ether (HMME)) and immune adjuvant (imiquimod (R837)). Using multiple tumour models, we demonstrate that combining nanosonosensitizers-augmented SDT with anti-PD-L1 induces an anti-tumour response, which not only arrests primary tumour progression, but also prevents lung metastasis. Furthermore, the combined treatment strategy offers a long-term immunological memory function, which can protect against tumour rechallenge after elimination of the initial tumours. Therefore, this work represents a proof-of-concept combinatorial tumour therapeutics based on noninvasive tumours-therapeutic modality with immunotherapy. |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27126]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yue, Wenwen,Chen, Liang,Yu, Luodan,et al. Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice[J]. NATURE COMMUNICATIONS,2019,10. |
| APA | Yue, Wenwen.,Chen, Liang.,Yu, Luodan.,Zhou, Bangguo.,Yin, Haohao.,...&Chen, Yu.(2019).Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice.NATURE COMMUNICATIONS,10. |
| MLA | Yue, Wenwen,et al."Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice".NATURE COMMUNICATIONS 10(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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