Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia
文献类型：期刊论文
| 作者 | Gao, Xiong; Zhu, Piao; Yu, Luodan; Yang, Liqun; Chen, Yu |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 8期号:9 |
| 关键词 | drug delivery mesoporous organosilica nanomedicine pain therapy stimuli-responsive nanoplatform |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201801350 |
| 文献子类 | Article |
| 英文摘要 | Local anesthetics have been extensively employed to treat postoperative pain, but they generally suffer from short acting duration and potential neurotoxicity under high local concentrations, which require the controlled and sustained releasing patterns of treatment drugs. In this work, it is reported, for the first time, the construction of hollow mesoporous organosilica nanoparticles (HMONs)-based nanoplatforms for localized delivery and controlled/sustained release of loaded ropivacaine for local anesthetics, which can be repeatedly triggered by either external ultrasound irradiation or acidity triggering to release the payload, causing on-demand and long-lasting analgesia. Based on the in vivo mouse model of incision pain, the controlled and sustained release of ropivacaine achieves more than six hours of continuous analgesia, which is almost three times longer as compared to single free ropivacaine injection. The low neurotoxicity and high biocompatibility of HMONs for nanoparticle-enabled analgesia are also demonstrated both in vitro and in vivo. This designed/constructed HMONs-based nanoplatform provides a potential methodology for clinical pain management via on-demand and long-lasting pain relief. |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27132]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Gao, Xiong,Zhu, Piao,Yu, Luodan,et al. Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia[J]. ADVANCED HEALTHCARE MATERIALS,2019,8(9). |
| APA | Gao, Xiong,Zhu, Piao,Yu, Luodan,Yang, Liqun,&Chen, Yu.(2019).Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia.ADVANCED HEALTHCARE MATERIALS,8(9). |
| MLA | Gao, Xiong,et al."Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia".ADVANCED HEALTHCARE MATERIALS 8.9(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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