Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing
文献类型：期刊论文
| 作者 | Zhang, Yu; Chang, Mengling; Bao, Feng; Xing, Min; Wang, Endian; Xu, Qing; Huan, Zhiguang; Guo, Feng; Chang, Jiang |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2019-04-07 |
| 卷号 | 11期号:13页码:6315 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c8nr09818b |
| 文献子类 | Article |
| 英文摘要 | Due to the complexity of the skin tissue structure, the regeneration of the entire skin, including skin appendages such as hair follicles, is a big challenge. In addition, skin trauma is often accompanied by bacterial infections that delay the wound healing. Therefore, developing wound dressings, which promote hair follicle regeneration and inhibit bacterial infection in the wound healing process, is of great clinical significance. In this study, Zn doped hollow mesoporous silica nanospheres (HMZS) were synthesized by a sol-gel method and a novel wound healing dressing was prepared by incorporation of drug ciprofloxacin hydrochloride (CiH)-loaded Zn containing mesoporous silica nanospheres (CiH-HMZS) into polycaprolactone (PCL) electrospun fibers. The CiH-HMZS/P nano-composite electrospun fibers exhibit the ability to promote angiogenesis and skin regeneration by releasing Si ions, and the activity to enhance hair follicle regeneration and inhibit bacterial growth by releasing zinc ions and achieve the synergistic antibacterial effect with both Zn ions and CiH in low concentrations. Thus, the CiH-HMZS/P nano-composite membrane is a promising multi-functional wound healing material for inhibiting bacterial growth in infected wounds and enhancing skin wound healing including hair follicle regeneration. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27198]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Yu,Chang, Mengling,Bao, Feng,et al. Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing[J]. NANOSCALE,2019,11(13):6315. |
| APA | Zhang, Yu.,Chang, Mengling.,Bao, Feng.,Xing, Min.,Wang, Endian.,...&Chang, Jiang.(2019).Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing.NANOSCALE,11(13),6315. |
| MLA | Zhang, Yu,et al."Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing".NANOSCALE 11.13(2019):6315. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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