Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing
文献类型：期刊论文
| 作者 | Ma, Hongshi; Zhou, Quan; Chang, Jiang; Wu, Chengtie |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 13期号:4页码:4302 |
| 关键词 | OPC-containing hydrogel scaffolds NIR laser responsive melanoma photothermal therapy skin wound healing |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b09496 |
| 文献子类 | Article |
| 英文摘要 | Grape-seed extracts contain rich flavonoids with oligomeric proanthocyanidins (OPC). In this study, OPC containing hydrogel scaffolds can function as a natural photothermal agent for melanoma therapy and bioactive biomaterial for wound healing. Inspired by grape seed extracts, OPC were explored as a photothermal agent and endowed the hydrogel scaffolds with excellent and controlled photothermal ability. The theological property of the hydrogel scaffolds responded to irradiation time of near infrared (NIR) laser, and OPC contents. The compressive mechanical property of the hydrogel scaffolds was well modulated by NIR laser irradiation with different impact durations. The controlled high temperature induced by OPC-containing hydrogel scaffolds under NIR laser irradiation could effectively kill melanoma cells and suppress tumor growth. In addition, OPC-containing hydrogel scaffolds supported the proliferation and migration of human dermal fibroblasts and human umbilical vein endothelial cells, as well as obviously promoted angiogenesis and skin regeneration in both tumor-caused and chronic wounds. Therefore, OPC-containing hydrogel scaffolds possessed controlled photothermal, rheological, and compressive mechanical properties under NIR laser stimuli, as well as excellent biocompatibility and bioactivity for melanoma therapy and wound healing. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27212]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Ma, Hongshi,Zhou, Quan,Chang, Jiang,et al. Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing[J]. ACS NANO,2019,13(4):4302. |
| APA | Ma, Hongshi,Zhou, Quan,Chang, Jiang,&Wu, Chengtie.(2019).Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing.ACS NANO,13(4),4302. |
| MLA | Ma, Hongshi,et al."Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing".ACS NANO 13.4(2019):4302. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。