Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions
文献类型：期刊论文
| 作者 | Ao, Haiyong; Yang, Shengbing; Nie, Bin'en; Fan, Qiming; Zhang, Quanchao; Zong, Jiajia; Guo, Shengrong; Zheng, Xuebin; Tang, Tingting |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2019-03-21 |
| 卷号 | 7期号:11页码:1951 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c8tb02425a |
| 文献子类 | Article |
| 英文摘要 | Implant infection is one of the most severe complications after orthopedic surgery. The construction of an antibacterial coating on orthopedic implants with release-killing or contact-killing is one of the most efficient strategies to prevent implant-related infections. Here we reported a hydroxypropyltrimethyl ammonium chloride chitosan (HACC) based multilayer modified plasma-sprayed porous titanium coating generated via the layer-by-layer covalent-immobilized method. We demonstrated that the multilayer coating inhibited the colonization and biofilm formation of several bacterial strains, including Staphylococcus aureus (ATCC 25923), methicillin-resistant Staphylococcus aureus (MSRA, ATCC 43300) and clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE 287), in vitro. HACC in the multilayer was released slowly with the degradation of the coating under the action of collagenase, further killing the planktonic bacteria, while the remaining HACC could kill the colonized bacteria. In a rat model of femur implants, the HACC-based multilayer-modified TCs effectively controlled the infection caused by MRSA and prevented bone destruction. Therefore, the HACC-based multilayer modified TCs with multiple antimicrobial properties could be a new potential ideal surface modification strategy to prevent implant associated infections. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27264]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Ao, Haiyong,Yang, Shengbing,Nie, Bin'en,et al. Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(11):1951. |
| APA | Ao, Haiyong.,Yang, Shengbing.,Nie, Bin'en.,Fan, Qiming.,Zhang, Quanchao.,...&Tang, Tingting.(2019).Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions.JOURNAL OF MATERIALS CHEMISTRY B,7(11),1951. |
| MLA | Ao, Haiyong,et al."Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions".JOURNAL OF MATERIALS CHEMISTRY B 7.11(2019):1951. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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