AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo
文献类型：期刊论文
| 作者 | Wang, Jing; Zhuo, Xiaolu; Xiao, Xiao; Mao, Rihua; Wang, Yong; Wang, Jianfang; Liu, Jun |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2019-02-21 |
| 卷号 | 11期号:7页码:3386 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c9nr00004f |
| 文献子类 | Article |
| 英文摘要 | Recent years have witnessed significant progress in the field of two-photon-activated photodynamic therapy (TP-PDT). However, traditional photosensitizer (PS)-based TP-PDT remains a critical challenge in clinics due to its low two-photon absorption cross sections. Here, we propose that the therapeutic activity of the current photosensitizer, sulfonated Al-phthalocyanine (AlPcS), can be efficiently excited via plasmonic-resonance energy transfer from the two-photon excited gold nanobipyramids (GBPs) and further generates cytotoxic singlet oxygen for cancer eradication. GBPs possess large two-photon absorption cross sections, excellent photostability, and biocompatibility, which can be used for a high two-photon light-harvesting material in biomedical applications. We compared the in vitro and in vivo capabilities of AlPcS-loaded GBPs as a TP-PDT agent for theranostic applications by benchmarking them against those of the extensively studied gold nanospheres (GNS) and nanorods (GNR). Although all these Au nanostructures could cause enhanced PS two-photon excitation fluorescence and improved singlet oxygen generation capability via the plasmonic resonance-energy transfer process, GBP-AlPcS exhibited the highest two-photon efficiency for photodynamic therapy. Remarkably, in vivo experiment results clearly indicated that the GBP-AlPcS caused efficient suppression of tumor growth and minimal adverse effects on orthotopic A549 human lung tumor xenografts. The system presents great efficiency in improving the treatment depth and precision of traditional photodynamic therapy. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27321]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Zhuo, Xiaolu,Xiao, Xiao,et al. AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo[J]. NANOSCALE,2019,11(7):3386. |
| APA | Wang, Jing.,Zhuo, Xiaolu.,Xiao, Xiao.,Mao, Rihua.,Wang, Yong.,...&Liu, Jun.(2019).AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo.NANOSCALE,11(7),3386. |
| MLA | Wang, Jing,et al."AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo".NANOSCALE 11.7(2019):3386. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。