Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction
文献类型：期刊论文
| 作者 | Gao, Shanshan; Lin, Han; Zhang, Haixian; Yao, Heliang; Chen, Yu; Shi, Jianlin |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-02-06 |
| 卷号 | 6期号:3 |
| 关键词 | cascade reaction nanocatalytic biomedicine nanocatalytic tumor therapy nanomedicine nanozymes |
| DOI | 10.1002/advs.201801733 |
| 文献子类 | Article |
| 英文摘要 | Emerging nanocatalytic tumor therapies based on nontoxic but catalytically active inorganic nanoparticles (NPs) for intratumoral production of high-toxic reactive oxygen species have inspired great research interest in the scientific community. Nanozymes exhibiting natural enzyme-mimicking catalytic activities have been extensively explored in biomedicine, mostly in biomolecular detection, yet much fewer researches are available on specific nanocatalytic tumor therapy. This study reports on the construction of an efficient biomimetic dual inorganic nanozyme-based nanoplatform, which triggers cascade catalytic reactions for tumor microenvironment responsive nanocatalytic tumor therapy based on ultrasmall Au and Fe3O4 NPs coloaded dendritic mesoporous silica NPs. Au NPs as the unique glucose oxidase-mimic nanozyme specifically catalyze beta-D-glucose oxidation into gluconic acid and H2O2, while the as produced H2O2 is subsequently catalyzed by the peroxidase-mimic Fe3O4 NPs to liberate high-toxic hydroxyl radicals for inducing tumor-cell death by the typical Fenton-based catalytic reaction. Extensive in vitro and in vivo evaluations have demonstrated high nanocatalytic-therapeutic efficacy with a desirable tumor-suppression rate (69.08%) based on these biocompatible composite nanocatalysts. Therefore, this work paves a way for nanocatalytic tumor therapy by rationally designing inorganic nanozymes with multienzymatic activities for achieving high therapeutic efficacy and excellent biosafety simultaneously. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27341]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Gao, Shanshan,Lin, Han,Zhang, Haixian,et al. Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction[J]. ADVANCED SCIENCE,2019,6(3). |
| APA | Gao, Shanshan,Lin, Han,Zhang, Haixian,Yao, Heliang,Chen, Yu,&Shi, Jianlin.(2019).Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction.ADVANCED SCIENCE,6(3). |
| MLA | Gao, Shanshan,et al."Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction".ADVANCED SCIENCE 6.3(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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