Hypoxia-Irrelevant Photonic Thermodynamic Cancer Nanomedicine
文献类型：期刊论文
| 作者 | Xiang, Huijing; Lin, Han; Yu, Luodan; Chen, Yu |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 13期号:2页码:2223 |
| 关键词 | tumor hypoxia thermodynamic therapy free radicals photothermal effect nanomedicine |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b08910 |
| 文献子类 | Article |
| 英文摘要 | The hypoxic tumor microenvironment severely lowers the therapeutic efficacy of oxygen-dependent anticancer modalities because tumor hypoxia hinders the generation of toxic reactive oxygen species. Here we report a thermodynamic cancer-therapeutic modality that employs oxygen-irrelevant free radicals generated from thermo-labile initiators for inducing cancer cell death. A free radical nanogenerator was engineered via direct growth of mesoporous silica layer onto the surface of two-dimensional Nb2C MXene nanosheets toward multifunctionality, where the mesopore provided the reservoirs for initiators and the MXene core acted as the photonic-thermal trigger at the near-infrared-II biowindow (NIR-II). Upon illumination by a 1064 nm NIR-II laser, the photothermal-conversion effect of Nb2C MXene induced the fast release and quick decomposition of the encapsulated initiators (AIPH) to produce free radicals, which promoted cancer cell apoptosis in both normoxic and hypoxic microenvironment. Systematic in vitro and in vivo evaluations have demonstrated the synergistic-therapeutic outcome of this intriguing photonic nanoplatform-enabled thermodynamic cancer therapy for completely eradicating the 4T1 tumors without recurrence by NIR-II laser irradiation. This work pioneers the thermodynamic therapy for oxygen-independent cancer treatment by photonic triggering at the NIR-II biowindow. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27353]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Xiang, Huijing,Lin, Han,Yu, Luodan,et al. Hypoxia-Irrelevant Photonic Thermodynamic Cancer Nanomedicine[J]. ACS NANO,2019,13(2):2223. |
| APA | Xiang, Huijing,Lin, Han,Yu, Luodan,&Chen, Yu.(2019).Hypoxia-Irrelevant Photonic Thermodynamic Cancer Nanomedicine.ACS NANO,13(2),2223. |
| MLA | Xiang, Huijing,et al."Hypoxia-Irrelevant Photonic Thermodynamic Cancer Nanomedicine".ACS NANO 13.2(2019):2223. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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