Nanocatalytic Tumor Therapy by Single-Atom Catalysts
文献类型：期刊论文
| 作者 | Huo, Minfeng; Wang, Liying; Wang, Youwei; Chen, Yu; Shi, Jianlin |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 13期号:2页码:2643 |
| 关键词 | single-atom catalyst nanocatalytic medicine tumor nanotherapy heterogeneous Fenton reaction photothermal effect |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b00457 |
| 文献子类 | Article |
| 英文摘要 | Initiating localized catalytic chemical reactions in tumor microenvironment (TME) can achieve appealing tumor-therapeutic efficacy concurrently with high specificity and desirable biosafety, which is mainly dependent on the high performance of biomedical nanocatalysts. This report demonstrates that PEGylated single-atom Fe-containing nanocatalysts (PSAF NCs) could effectively trigger the in situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (center dot OH) selectively under the acidic TME. Based on density functional theory, it has been theoretically uncovered that the nanocatalysts could specifically catalyze the heterogeneous Fenton reaction via a proton-mediated H2O2-homolytic pathway. These generated radicals could not only lead to the apoptotic cell death of malignant tumors, but also induce the accumulation of lipid peroxides, causing tumor cell ferroptosis, which synergistically lead to an impressive tumor suppression outcome. In the meantime, the favorable biodegradability and biocompatibility of PSAF NCs also guarantee their desirable biosafety both in vivo and in vitro. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27355]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Huo, Minfeng,Wang, Liying,Wang, Youwei,et al. Nanocatalytic Tumor Therapy by Single-Atom Catalysts[J]. ACS NANO,2019,13(2):2643. |
| APA | Huo, Minfeng,Wang, Liying,Wang, Youwei,Chen, Yu,&Shi, Jianlin.(2019).Nanocatalytic Tumor Therapy by Single-Atom Catalysts.ACS NANO,13(2),2643. |
| MLA | Huo, Minfeng,et al."Nanocatalytic Tumor Therapy by Single-Atom Catalysts".ACS NANO 13.2(2019):2643. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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