Nanocatalysts-Augmented and Photothermal-Enhanced Tumor-Specific Sequential Nanocatalytic Therapy in Both NIR-I and NIR-II Biowindows
文献类型：期刊论文
| 作者 | Feng, Wei; Han, Xiuguo; Wang, Rongyan; Gao, Xiang; Hu, Ping; Yue, Wenwen; Chen, Yu; Shi, Jianlin |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 31期号:5 |
| 关键词 | cancer nanocatalytic medicine synergistic therapy theranostics tumor microenvironment |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201805919 |
| 文献子类 | Article |
| 英文摘要 | The tumor microenvironment (TME) has been increasingly recognized as a crucial contributor to tumorigenesis. Based on the unique TME for achieving tumor-specific therapy, here a novel concept of photothermal-enhanced sequential nanocatalytic therapy in both NIR-I and NIR-II biowindows is proposed, which innovatively changes the condition of nanocatalytic Fenton reaction for production of highly efficient hydroxyl radicals (center dot OH) and consequently suppressing the tumor growth. Evidence suggests that glucose plays a vital role in powering cancer progression. Encouraged by the oxidation of glucose to gluconic acid and H2O2 by glucose oxidase (GOD), an Fe3O4/GOD-functionalized polypyrrole (PPy)-based composite nanocatalyst is constructed to achieve diagnostic imaging-guided, photothermal-enhanced, and TME-specific sequential nanocatalytic tumor therapy. The consumption of intratumoral glucose by GOD leads to the in situ elevation of the H2O2 level, and the integrated Fe3O4 component then catalyzes H2O2 into highly toxic center dot OH to efficiently induce cancer-cell death. Importantly, the high photothermal-conversion efficiency (66.4% in NIR-II biowindow) of the PPy component elevates the local tumor temperature in both NIR-I and NIR-II biowindows to substaintially accelerate and improve the nanocatalytic disproportionation degree of H2O2 for enhancing the nanocatalytic-therapeutic efficacy, which successfully achieves a remarkable synergistic anticancer outcome with minimal side effects. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27362]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Feng, Wei,Han, Xiuguo,Wang, Rongyan,et al. Nanocatalysts-Augmented and Photothermal-Enhanced Tumor-Specific Sequential Nanocatalytic Therapy in Both NIR-I and NIR-II Biowindows[J]. ADVANCED MATERIALS,2019,31(5). |
| APA | Feng, Wei.,Han, Xiuguo.,Wang, Rongyan.,Gao, Xiang.,Hu, Ping.,...&Shi, Jianlin.(2019).Nanocatalysts-Augmented and Photothermal-Enhanced Tumor-Specific Sequential Nanocatalytic Therapy in Both NIR-I and NIR-II Biowindows.ADVANCED MATERIALS,31(5). |
| MLA | Feng, Wei,et al."Nanocatalysts-Augmented and Photothermal-Enhanced Tumor-Specific Sequential Nanocatalytic Therapy in Both NIR-I and NIR-II Biowindows".ADVANCED MATERIALS 31.5(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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