Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure
文献类型：期刊论文
| 作者 | Wang, Xiaotong; Wang, Leyu; Wu, Qiang; Bao, Feng; Yang, Huangtian; Qiu, Xiaozhong; Chang, Jiang |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2019-01-09 |
| 卷号 | 11期号:1页码:1449 |
| 关键词 | calcium silicate chitosan cardiac patch bioactive ions aligned nanostructure |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b17754 |
| 文献子类 | Article |
| 英文摘要 | Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive scaffold that has positive effects on cardiac cell behaviors and cardiac tissue repair. In this study, we for the first time demonstrated that Si ions evidently stimulated the expression of cardiac-specific genes and proliferation of neonatal rat cardiomyocytes (NRCMs) at concentration ranges of 0.13-10.78 ppm. Accordingly, the optimized concentrations of calcium silicate (CS) were incorporated into the controllable aligned chitosan electrospun nanofibers, constructing the composite cardiac patch scaffolds. These scaffolds showed synergistic effect of bioactive chemical and structural signals on both cardiomyocytes and endothelial cells with aligned cell morphology and enhanced viability and function characterized by upregulated expressions of cardiac and angiogenic specific markers, improved myofilament structure, and better Ca2+ transients of NRCMs as compared to the scaffolds free of CS component or with disordered structures. The in vivo studies further demonstrated that the NRCM-seeded aligned CS/chitosan cardiac patch evidently improved cardiac function via limiting the scar area and promoting angiogenesis in postmyocardial infarction rats. Conclusively, our study highlights the potential application of bioactive ions and nanostructured biomaterials in CTE, and the CS/chitosan composite cardiac patch may be a promising scaffold for repair of infarcted myocardium. |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27403]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Xiaotong,Wang, Leyu,Wu, Qiang,et al. Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(1):1449. |
| APA | Wang, Xiaotong.,Wang, Leyu.,Wu, Qiang.,Bao, Feng.,Yang, Huangtian.,...&Chang, Jiang.(2019).Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure.ACS APPLIED MATERIALS & INTERFACES,11(1),1449. |
| MLA | Wang, Xiaotong,et al."Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure".ACS APPLIED MATERIALS & INTERFACES 11.1(2019):1449. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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