Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
文献类型：期刊论文
| 作者 | Yi, Min; Li, Hekai; Wong, Xiaoya; Yan, Jianyun; Gao, Long; He, Yinyan; Zhong, Xinglong; Cai, Yanbin; Feng, Weijing; Wen, Zhanpeng |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-01-09 |
| 卷号 | 6期号:1 |
| 关键词 | acute myocardial infarction bioactive ions therapy |
| ISSN号 | 2198-3844 |
| DOI | 10.1002/advs.201801260 |
| 文献子类 | Article |
| 英文摘要 | Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border-zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell-cell communications. Here, the paracrine stimulatory function of bioactive ions derived from biomaterials is integrated into the clinical concept of administration and proposed "ion therapy" as a novel strategy for myocardial infarction. In vitro, silicon- enriched ion extracts significantly increase cardiomyocyte viability and promote cell-cell communications, thus stimulating vascular formation via a paracrine effect under glucose/oxygen deprived conditions. In vivo, by intravenous injection, the bioactive silicon ions act as "diplomats" and promote crosstalk in myocardial cells, stimulate angiogenesis, and improve cardiac function post-myocardial infarction. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27404]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yi, Min,Li, Hekai,Wong, Xiaoya,et al. Ion Therapy: A Novel Strategy for Acute Myocardial Infarction[J]. ADVANCED SCIENCE,2019,6(1). |
| APA | Yi, Min.,Li, Hekai.,Wong, Xiaoya.,Yan, Jianyun.,Gao, Long.,...&Chen, Minsheng.(2019).Ion Therapy: A Novel Strategy for Acute Myocardial Infarction.ADVANCED SCIENCE,6(1). |
| MLA | Yi, Min,et al."Ion Therapy: A Novel Strategy for Acute Myocardial Infarction".ADVANCED SCIENCE 6.1(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。