Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy
文献类型:期刊论文
作者 | Huo, Minfeng; Wang, Liying; Zhang, Linlin; Wei, Chenyang; Chen, Yu; Shi, Jianlin |
刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
出版日期 | 2019-12-31 |
ISSN号 | 1433-7851 |
关键词 | cyanobacteria oxygenation photodynamic therapy photosensitizers photosynthesis |
DOI | 10.1002/anie.201912824 |
文献子类 | Article; Early Access |
英文摘要 | Sustained tumor oxygenation is of critical importance during type-II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for the generation of reactive oxygen species. Herein, the modification of photosynthetic cyanobacteria with the photosensitizer chlorin e6 (ce6) to form ce6-integrated photosensitive cells, termed ceCyan, is reported. Upon 660 nm laser irradiation, sustained photosynthetic O-2 evolution by the cyanobacteria and the immediate generation of reactive singlet oxygen species (O-1(2)) by the integrated photosensitizer could be almost simultaneously achieved for tumor therapy using type-II PDT both in vitro and in vivo. This work contributes a conceptual while practical paradigm for biocompatible and effective PDT using hybrid microorganisms, displaying a bright future in clinical PDT by microbiotic nanomedicine. |
WOS关键词 | BACTERIA ; NANOPARTICLES ; CANCER |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
源URL | [http://ir.sic.ac.cn/handle/331005/27452] |
专题 | 中国科学院上海硅酸盐研究所 |
推荐引用方式 GB/T 7714 | Huo, Minfeng,Wang, Liying,Zhang, Linlin,et al. Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019. |
APA | Huo, Minfeng,Wang, Liying,Zhang, Linlin,Wei, Chenyang,Chen, Yu,&Shi, Jianlin.(2019).Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. |
MLA | Huo, Minfeng,et al."Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019). |
入库方式: OAI收割
来源:上海硅酸盐研究所
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