中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy

文献类型:期刊论文

作者Huo, Minfeng; Wang, Liying; Zhang, Linlin; Wei, Chenyang; Chen, Yu; Shi, Jianlin
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2019-12-31
ISSN号1433-7851
关键词cyanobacteria oxygenation photodynamic therapy photosensitizers photosynthesis
DOI10.1002/anie.201912824
文献子类Article; Early Access
英文摘要Sustained tumor oxygenation is of critical importance during type-II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for the generation of reactive oxygen species. Herein, the modification of photosynthetic cyanobacteria with the photosensitizer chlorin e6 (ce6) to form ce6-integrated photosensitive cells, termed ceCyan, is reported. Upon 660 nm laser irradiation, sustained photosynthetic O-2 evolution by the cyanobacteria and the immediate generation of reactive singlet oxygen species (O-1(2)) by the integrated photosensitizer could be almost simultaneously achieved for tumor therapy using type-II PDT both in vitro and in vivo. This work contributes a conceptual while practical paradigm for biocompatible and effective PDT using hybrid microorganisms, displaying a bright future in clinical PDT by microbiotic nanomedicine.
WOS关键词BACTERIA ; NANOPARTICLES ; CANCER
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
源URL[http://ir.sic.ac.cn/handle/331005/27452]  
专题中国科学院上海硅酸盐研究所
推荐引用方式
GB/T 7714
Huo, Minfeng,Wang, Liying,Zhang, Linlin,et al. Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019.
APA Huo, Minfeng,Wang, Liying,Zhang, Linlin,Wei, Chenyang,Chen, Yu,&Shi, Jianlin.(2019).Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Huo, Minfeng,et al."Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019).

入库方式: OAI收割

来源:上海硅酸盐研究所

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