Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy
文献类型：期刊论文
| 作者 | Tang, Zhong-min; Liu, Yan-yan; Ni, Da-long; Zhou, Jia-jia; Zhang, Meng; Zhao, Pei-ran; Lv, Bin; Wang, Han; Jin, Da-yong; Bu, Wen-bo |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2019-12-31 |
| 关键词 | biodegradable nanoprodrugs MgO2 nanosheets molecular dynamic therapy tumor microenvironment |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201904011 |
| 文献子类 | Article; Early Access |
| 英文摘要 | Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic center dot OH to kill tumor cells. |
| WOS关键词 | REACTIVE OXYGEN ; HYDROGEN-PEROXIDE ; GROWTH ; TRANSDUCTION ; MAGNESIUM |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27455]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Tang, Zhong-min,Liu, Yan-yan,Ni, Da-long,et al. Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy[J]. ADVANCED MATERIALS,2019. |
| APA | Tang, Zhong-min.,Liu, Yan-yan.,Ni, Da-long.,Zhou, Jia-jia.,Zhang, Meng.,...&Bu, Wen-bo.(2019).Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy.ADVANCED MATERIALS. |
| MLA | Tang, Zhong-min,et al."Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy".ADVANCED MATERIALS (2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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