中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide

文献类型:期刊论文

作者Wang, Lanyu; Qiu, Jiajun; Guo, Jingshu; Wang, Donghui; Qian, Shi; Cao, Huiliang; Liu, Xuanyong
刊名ACS BIOMATERIALS SCIENCE & ENGINEERING
出版日期2019-12-30
卷号5期号:12页码:6414
ISSN号2373-9878
关键词human gingival fibroblasts soft tissue sealing reduced graphene oxide sp(2) domains
DOI10.1021/acsbiomaterials.9b00497
文献子类Article
英文摘要Long-term function of dental implants relies on not only stable osseointegration but also strong soft tissue-sealing ability. Ideal soft tissue sealing around implants is an effective protective barrier between the external environment and alveolar bone, preventing the invasion of bacteria that is considered as a vital trigger of irreversible marginal bone loss. Carbon-based materials have been reported to be beneficial to soft tissue sealing, which can be regulated through the hybridization type of carbon atoms (sp(2) or sp(3)), but its internal mechanism is still not clear. In this work, graphene oxide with both sp(2) - and sp(3)-hybridized carbons was electrophoretic deposited on titanium and reduced to regulate the hybridization type of carbon atoms to investigate its effect and possible mechanism on human gingival fibroblasts (HGFs). X- ray photoelectron spectroscopy and Raman mapping test show the increase of sp(2) domain content and the decrease of their size after reduction. Through computer simulation, the possible mechanism of the decrease of sp(2) domain size was proposed. In vitro studies disclose that the HGFs exhibit higher proliferation rate, better adhesion, and migration ability with the increase of sp(2) domains and the decrease of their sizes. It may be due to the amount and size of sp(2) domains that synergistically regulate the amount and properties of adsorbed proteins, thereby influencing the cellular behaviors of HGFs. Our results may offer a different perspective on material designing and academic research to enhance the soft tissue integration of implants.
WOS关键词CARBON NANOTUBES ; IN-VITRO ; AQUEOUS DISPERSIONS ; GRAPHITE OXIDE ; TITANIUM ; REDUCTION ; NANOSHEETS ; MECHANISM ; SURFACE ; FILMS
WOS研究方向Materials Science
语种英语
出版者AMER CHEMICAL SOC
源URL[http://ir.sic.ac.cn/handle/331005/27458]  
专题中国科学院上海硅酸盐研究所
推荐引用方式
GB/T 7714
Wang, Lanyu,Qiu, Jiajun,Guo, Jingshu,et al. Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(12):6414.
APA Wang, Lanyu.,Qiu, Jiajun.,Guo, Jingshu.,Wang, Donghui.,Qian, Shi.,...&Liu, Xuanyong.(2019).Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(12),6414.
MLA Wang, Lanyu,et al."Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.12(2019):6414.

入库方式: OAI收割

来源:上海硅酸盐研究所

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