Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy
文献类型：期刊论文
| 作者 | Yin, Haohao; Guan, Xin; Lin, Han; Pu, Yinying; Fang, Yan; Yue, Wenwen; Zhou, Bangguo; Wang, Qiao; Chen, Yu; Xu, Huixiong |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-12-31 |
| 关键词 | MXene nitric oxide photonic nanomedicine sequential activation thermogaseous therapy |
| DOI | 10.1002/advs.201901954 |
| 文献子类 | Article; Early Access |
| 英文摘要 | Local photothermal hyperthermia for tumor ablation and specific stimuliresponsive gas therapy feature the merits of remote operation, noninvasive intervention, and in situ tumor-specific activation in cancer-therapeutic biomedicine. Inspired by synergistic/sequential therapeutic modality, herein a novel therapeutic modality is reported based on the construction of two-dimensional (2D) core/shell-structured Nb2C-MSNs-SNO composite nanosheets for photonic thermogaseous therapy. A phototriggered thermogas-generating nanoreactor is designed via mesoporous silica layer coating on the surface of Nb2C MXene nanosheets, where the mesopores provide the reservoirs for NO donor (S-nitrosothiol (RSNO)), and the core of Nb2C produces heat shock upon second near-infrared biowindow (NIR-II) laser irradiation. The Nb2C-MSNs-SNO-enabled photonic thermogaseous therapy undergoes a sequential process of phototriggered heat production from the core of Nb2C and thermotriggered NO generation, together with photoacoustic-imaging (PAI) guidance and monitoring. The constructed Nb2C-MSNs-SNO nanoreactors exhibit high-NIR-induced photothermal effect, intense NIR-controlled NO release, and desirable PAI performance. Based on these unique theranostic properties of Nb2C-MSNs-SNO nanocomposites, sequential photonic thermogaseous therapy with limited systematic toxicity on efficiently suppressing tumor growth is achieved by PAI-guided NIR-controlled NO release as well as heat generation. Such a thermogaseous approach representes a stimuli-selective strategy for synergistic/sequential cancer treatment. |
| WOS关键词 | NITRIC-OXIDE DONORS ; PHOTODYNAMIC THERAPY ; CHECKPOINT BLOCKADE ; TUMOR ; COMBINATION ; RELEASE ; GENERATION ; NANOSHEETS ; PLATFORM ; MXENES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27481]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yin, Haohao,Guan, Xin,Lin, Han,et al. Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy[J]. ADVANCED SCIENCE,2019. |
| APA | Yin, Haohao.,Guan, Xin.,Lin, Han.,Pu, Yinying.,Fang, Yan.,...&Xu, Huixiong.(2019).Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy.ADVANCED SCIENCE. |
| MLA | Yin, Haohao,et al."Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy".ADVANCED SCIENCE (2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。