Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability
文献类型：期刊论文
| 作者 | Qian, Xiaoqin; Han, Xiaoxia; Yu, Luodan; Xu, Tianming; Chen, Yu |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2019-12-31 |
| ISSN号 | 1616-301X |
| 关键词 | contrast agents magnetic resonance imaging manganese oxide manganese-based nanoparticles nanomedicine |
| DOI | 10.1002/adfm.201907066 |
| 文献子类 | Review; Early Access |
| 英文摘要 | Transition metal-based nanoparticles have shown their broad applications in versatile biomedical applications. Although traditional iron-based nanoparticles have been extensively explored in biomedicine, transition metal manganese (Mn)-based nanoparticulate systems have emerged as a multifunctional nanoplatform with their intrinsic physiochemical property and biological effect for satisfying the strict biomedical requirements. This comprehensive review focuses on recent progress of Mn-based functional nanoplatforms in biomedicine with the particular discussion on their elaborate construction, physiochemical property, and theranostic applicability. Several Mn-based nanosystems are discussed in detail, including solid/hollow MnOx nanoparticles, 2D MnOx nanosheets, MnOx-silica/mesoporous silica nanoparticles, MnOx-Fe3O4 nanoparticles, MnOx-Au, MnOx-fluorescent nanoparticles, Mn-based organic composite nanosystem, and some specific/unique Mn-based nanocomposites. Their versatile biomedical applications include pH/reducing-responsive T-1-weighted positive magnetic resonance imaging, controlled drug loading/delivery/release, protection of neurological disorder, photothermal hyperthermia, photodynamic therapy, chemodynamic therapy, alleviation of tumor hypoxia, immunotherapy, and some specific synergistic therapies, which are based on their disintegration behavior under the mildly acidic/reducing condition, multiple enzyme-mimicking activity, catalytic-triggering Fenton reaction, etc. The biological effects and biocompatibility of these Mn-based nanosystems are also discussed, accompanied with a discussion on challenges/critical issues and an outlook on the future developments and clinical-translation potentials of these intriguing Mn-based functional nanoplatforms. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; GADOLINIUM OXIDE NANOPARTICLES ; MRI CONTRAST AGENTS ; PRUSSIAN BLUE NANOCUBES ; SELECTIVE DUAL FUNCTIONALIZATION ; ENHANCED PHOTODYNAMIC THERAPY ; SOLID TUMOR MICROENVIRONMENT ; TARGETED MAGNETIC-RESONANCE ; MXENES COMPOSITE NANOSHEETS ; COATED MNO NANOPARTICLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27495]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Qian, Xiaoqin,Han, Xiaoxia,Yu, Luodan,et al. Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability[J]. ADVANCED FUNCTIONAL MATERIALS,2019. |
| APA | Qian, Xiaoqin,Han, Xiaoxia,Yu, Luodan,Xu, Tianming,&Chen, Yu.(2019).Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability.ADVANCED FUNCTIONAL MATERIALS. |
| MLA | Qian, Xiaoqin,et al."Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability".ADVANCED FUNCTIONAL MATERIALS (2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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