Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma
文献类型：期刊论文
| 作者 | Meng, Xianfu; Zhang, Hua; Zhang, Meng; Wang, Baoming; Liu, Yanyan; Wang, Yan; Fang, Xiangming; Zhang, Jiawen; Yao, Zhenwei; Bu, Wenbo |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-12-31 |
| 关键词 | H-2 release HMSN@AB@PEG negative CT contrast agents osteosarcoma tumor acidic microenvironment |
| DOI | 10.1002/advs.201901214 |
| 文献子类 | Article; Early Access |
| 英文摘要 | The current positive computed tomography (CT) contrast agents (PCTCAs) including clinical iodides, present high CT density value (CT-DV). However, they are incapable for the accurate diagnosis of some diseases with high CT-DV, such as osteosarcoma. Because bones and PCTCAs around osteosarcoma generate similar X-ray attenuations. Here, an innovative strategy of negative CT contrast agents (NCTCAs) to reduce the CT-DV of osteosarcoma is proposed, contributing to accurate detection of osteosarcoma. Hollow mesoporous silica nanoparticles, loading ammonia borane molecules and further modified by polyethylene glycol, are synthesized as NCTCAs for the diagnosis of osteosarcoma. The nanocomposites can produce H-2 in situ at osteosarcoma areas by responding to the acidic microenvironment of osteosarcoma, resulting in nearly 20 times reduction of CT density in osteosarcoma. This helps form large CT density contrast between bones and osteosarcoma, and successfully achieves accurate diagnosis of osteosarcoma. Meanwhile, The NCTCAs strategy greatly expands the scope of CT application, and provides profound implications for the precise clinical diagnosis, treatment, and prognosis of diseases. |
| WOS关键词 | NERVOUS-SYSTEM LYMPHOMA ; AMMONIA-BORANE ; UP-CONVERSION ; HEART-DISEASE ; IN-VIVO ; TUMOR ; ANGIOGRAPHY ; DEHYDROGENATION ; LUMINESCENCE ; PERFORMANCE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27526]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Meng, Xianfu,Zhang, Hua,Zhang, Meng,et al. Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma[J]. ADVANCED SCIENCE,2019. |
| APA | Meng, Xianfu.,Zhang, Hua.,Zhang, Meng.,Wang, Baoming.,Liu, Yanyan.,...&Bu, Wenbo.(2019).Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma.ADVANCED SCIENCE. |
| MLA | Meng, Xianfu,et al."Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma".ADVANCED SCIENCE (2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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