Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine
文献类型：期刊论文
| 作者 | Cui, Xinwu; Han, Xiaoxia; Yu, Luodan; Zhang, Bo; Chen, Yu |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2019-10-30 |
| 卷号 | 28 |
| 关键词 | Ultrasound imaging Ultrasound therapy Nanomedicine Chemistry Nanoparticles |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2019.100773 |
| 文献子类 | Review |
| 英文摘要 | Chemistry has long been playing its specific role in ultrasound-responsive theranostic biomedicine in the form of microbubbles, which clinically provide the dynamic detection of macro and microvasculature by continuous expanding and contracting under the alternating ultrasound pressure. However, microbubbles' large particle size severely hinders their efficiency in ultrasound-triggered diseases theranostics as they only transport within the blood vessels. Fortunately, the scientific community recently seeks solving strategies from the advances of chemistry and nanomedicine by rationally designing and fabricating versatile intelligent and multifunctional ultrasound-responsive nanosystems/nanoplatforms to solve the critical issues of traditional microbubbles and routine nanosystems, which is herein classified as "ultrasound-responsive nanomedicine". This review discusses and clarifies the intrinsic chemistry (e.g., material chemistry, surface chemistry, physiochemistry and biochemistry) and design principle of versatile nanosystems/nanoplatforms with unique ultrasound response not only for diagnostic bioimaging (single and/or multi-modality ultrasound imaging), but also for multiple ultrasound-triggered therapeutic applications. Based on the unique ultrasound features of high tissue-penetrating capability, non-invasiveness, easy accessibility and relatively mature apparatus, this review finally elucidates the unresolved critical issues/challenges and future clinical-translation potentials of this intriguing "ultrasound-responsive nanomedicine". (C) 2019 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; GENERATING MINERALIZED NANOPARTICLES ; MESOPOROUS SILICA NANOPARTICLES ; TRIGGERED DRUG-DELIVERY ; FOCUSED ULTRASOUND ; SONODYNAMIC THERAPY ; CONTRAST AGENTS ; IN-VIVO ; TARGETED ULTRASOUND ; TIO2 NANOPARTICLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27529]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Cui, Xinwu,Han, Xiaoxia,Yu, Luodan,et al. Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine[J]. NANO TODAY,2019,28. |
| APA | Cui, Xinwu,Han, Xiaoxia,Yu, Luodan,Zhang, Bo,&Chen, Yu.(2019).Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine.NANO TODAY,28. |
| MLA | Cui, Xinwu,et al."Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine".NANO TODAY 28(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。