Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy
文献类型:期刊论文
作者 | Wang, Liying; Zhang, Tingting; Huo, Minfeng; Guo, Jia; Chen, Yu; Xu, Huixiong |
刊名 | SMALL |
出版日期 | 2019-11-30 |
卷号 | 15期号:47 |
ISSN号 | 1613-6810 |
关键词 | DNA damage iridium nucleus-targeting photothermal radiotherapy |
DOI | 10.1002/smll.201903254 |
文献子类 | Article |
英文摘要 | Prominent tumor-cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor-specific photonic hyperthermia-synergized radiotherapy. To endow the NCs with qualified cell nucleus-targeting performance, polyethylene glycol (PEG)-modified Ir NCs are decorated with alpha(v)beta(3) integrin-targeting cyclic arginine-glycine-aspartic (c(RGDyC)), designated as RGD, peptides and human immunodeficiency virus-1 transactivator of transcription protein(TAT), respectively, facilitating the tumor-cell-membrane (with overexpressed alpha(v)beta(3) integrin) and cell-nucleus targeting. The formulated Ir-RGD-TAT (Ir-R/T) NCs are demonstrated to accumulate inside the nucleus of tumor cells and generate effective DNA lesions upon X-ray irradiation. Further in vivo evaluations verify the satisfactory carcinoma destruction performance against 4T1 tumor xenografts. Importantly, the intriguing photonic NIR adsorption of Ir-R/T NCs has enabled the hyperthermia therapeutics accompanied with photoacoustic imaging modalities, achieving clinically promising biocompatible multifunctional radiosensitized nanoplatforms for effective tumor therapeutics. |
WOS关键词 | TOTAL MESORECTAL EXCISION ; TUMOR MICROENVIRONMENT ; RECEPTOR-BINDING ; RECTAL-CANCER ; NANOPARTICLES ; THERAPY ; DELIVERY ; GOLD ; GAMMA-H2AX ; RADIATION |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
源URL | [http://ir.sic.ac.cn/handle/331005/27534] |
专题 | 中国科学院上海硅酸盐研究所 |
推荐引用方式 GB/T 7714 | Wang, Liying,Zhang, Tingting,Huo, Minfeng,et al. Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy[J]. SMALL,2019,15(47). |
APA | Wang, Liying,Zhang, Tingting,Huo, Minfeng,Guo, Jia,Chen, Yu,&Xu, Huixiong.(2019).Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy.SMALL,15(47). |
MLA | Wang, Liying,et al."Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy".SMALL 15.47(2019). |
入库方式: OAI收割
来源:上海硅酸盐研究所
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