Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy
文献类型：期刊论文
| 作者 | Wang, Liying; Zhang, Tingting; Huo, Minfeng; Guo, Jia; Chen, Yu; Xu, Huixiong |
| 刊名 | SMALL
 |
| 出版日期 | 2019-11-30 |
| 卷号 | 15期号:47 |
| 关键词 | DNA damage iridium nucleus-targeting photothermal radiotherapy |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201903254 |
| 文献子类 | Article |
| 英文摘要 | Prominent tumor-cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor-specific photonic hyperthermia-synergized radiotherapy. To endow the NCs with qualified cell nucleus-targeting performance, polyethylene glycol (PEG)-modified Ir NCs are decorated with alpha(v)beta(3) integrin-targeting cyclic arginine-glycine-aspartic (c(RGDyC)), designated as RGD, peptides and human immunodeficiency virus-1 transactivator of transcription protein(TAT), respectively, facilitating the tumor-cell-membrane (with overexpressed alpha(v)beta(3) integrin) and cell-nucleus targeting. The formulated Ir-RGD-TAT (Ir-R/T) NCs are demonstrated to accumulate inside the nucleus of tumor cells and generate effective DNA lesions upon X-ray irradiation. Further in vivo evaluations verify the satisfactory carcinoma destruction performance against 4T1 tumor xenografts. Importantly, the intriguing photonic NIR adsorption of Ir-R/T NCs has enabled the hyperthermia therapeutics accompanied with photoacoustic imaging modalities, achieving clinically promising biocompatible multifunctional radiosensitized nanoplatforms for effective tumor therapeutics. |
| WOS关键词 | TOTAL MESORECTAL EXCISION ; TUMOR MICROENVIRONMENT ; RECEPTOR-BINDING ; RECTAL-CANCER ; NANOPARTICLES ; THERAPY ; DELIVERY ; GOLD ; GAMMA-H2AX ; RADIATION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27534]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Liying,Zhang, Tingting,Huo, Minfeng,et al. Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy[J]. SMALL,2019,15(47). |
| APA | Wang, Liying,Zhang, Tingting,Huo, Minfeng,Guo, Jia,Chen, Yu,&Xu, Huixiong.(2019).Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy.SMALL,15(47). |
| MLA | Wang, Liying,et al."Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy".SMALL 15.47(2019). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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