Dose-response relationships between copper and its biocompatibility/antibacterial activities
文献类型：期刊论文
| 作者 | Li, Kunqiang; Xia, Chao; Qiao, Yuqin; Liu, Xuanyong |
| 刊名 | JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2019-09-30 |
| 卷号 | 55页码:127 |
| 关键词 | Copper Antibacterial Osteogenesis Angiogenesis Dose-response relationship |
| ISSN号 | 0946-672X |
| DOI | 10.1016/j.jtemb.2019.06.015 |
| 文献子类 | Article |
| 英文摘要 | Background: Copper has already been widely used in the modification of biomaterials because it possesses multifunctional biological effects like osteogenic, angiogenic and antibacterial activities. However, it is still not clear how different cell lines and bacteria will respond to different concentrations of Cu2+, which is very critical to the application of copper-doped implants. Methods: This study aimed to explore the dose-response relationships of Cu2+ and its biological effects in vitro. Rat bone marrow mesenchymal stem cell (rBMSCs), mouse osteoblastic cell line (MC3T3-E1), and human umbilical vein endothelial cells (HUVECs) were used to evaluate cellular behaviors. Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were used to evaluate bacterial behaviors. Results: Results showed that the HUVEC5 exhibited significantly higher tolerance to copper ions than MC3T3-E1 and rBMSCs. The IC50 values of copper for HUVEC5, MC3T3-E1 and HUVEC5 were approximated to 327.9 mu M, 134.6 mu M, and 0.7 mu M, respectively. Besides, the threshold concentration of copper for effective inhibition against bacteria growth is 37 mu M. When the concentration exceeded the threshold value, antibacterial activity could increase dramatically. Conclusions: These results altogether establish a technological foundation for the application of copper-doped biomaterials in bone growth and remodeling. |
| WOS关键词 | MESOPOROUS BIOACTIVE GLASS ; IN-VITRO ; ANTIBACTERIAL ACTIVITY ; SURFACE MODIFICATION ; TITANIUM SURFACE ; ANGIOGENESIS ; IMPLANTATION ; BIOCHEMISTRY ; INFECTION ; CU2+ |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | ELSEVIER GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27540]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Li, Kunqiang,Xia, Chao,Qiao, Yuqin,et al. Dose-response relationships between copper and its biocompatibility/antibacterial activities[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2019,55:127. |
| APA | Li, Kunqiang,Xia, Chao,Qiao, Yuqin,&Liu, Xuanyong.(2019).Dose-response relationships between copper and its biocompatibility/antibacterial activities.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,55,127. |
| MLA | Li, Kunqiang,et al."Dose-response relationships between copper and its biocompatibility/antibacterial activities".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 55(2019):127. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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