Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects
文献类型：期刊论文
| 作者 | Lu, Xiang; Li, Kai; Xie, Youtao; Qi, Shengcai; Shen, Qingyi; Yu, Jiangming; Huang, Liping; Zheng, Xuebin |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2019-01-30 |
| 卷号 | 107期号:1页码:12 |
| 关键词 | macrophage immunomodulation boron calcium silicate coatings osteogenesis |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.36456 |
| 文献子类 | Article |
| 英文摘要 | Osteoimmunology has revealed the importance of a favorable immune response for successful biomaterial-mediated osteogenesis. Boron-incorporated calcium silicate (Ca11Si4B2O22, B-CS) coating has been reported as a potential candidate for improving osteogenesis in orthopedic applications in vitro. However, relatively little is known about its effects on the immune response and subsequent osteogenesis. In this work, the immunomodulatory properties of the B-CS coating and its specific mechanism of action were explored. We found that the B-CS coating decreased M1 polarization and converted macrophages to the M2 phenotype via restraining the toll-like receptor signaling pathway, thus inducing a significant reduction in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines. Moreover, the B-CS coating inhibited osteoclastogenesis and osteoclastic activities by downregulating osteoclastogenic genes and inhibiting the RANKL/RANK system. BMP2 and VEGF were also significantly upregulated by macrophages and bone mesenchymal stem cells, leading to activation of the BMP2 signaling pathway and subsequent upregulation of osteogenesis-associated genes, finally promoting osteogenic differentiation. These findings show that the B-CS coating could be a promising coating material for hip and knee implants. Furthermore, incorporation of the element boron into bioceramic coatings could be a good strategy in the design of bone biomaterials with beneficial immune responses. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 12-24, 2019. |
| WOS关键词 | BIOACTIVE GLASS SCAFFOLDS ; MESENCHYMAL STEM-CELLS ; TITANIUM SURFACE ; ONCOSTATIN M ; DIETARY BORON ; MACROPHAGE ; INFLAMMATION ; TOPOGRAPHY ; DIFFERENTIATION ; INDUCTION |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27571]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Lu, Xiang,Li, Kai,Xie, Youtao,et al. Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2019,107(1):12. |
| APA | Lu, Xiang.,Li, Kai.,Xie, Youtao.,Qi, Shengcai.,Shen, Qingyi.,...&Zheng, Xuebin.(2019).Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,107(1),12. |
| MLA | Lu, Xiang,et al."Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 107.1(2019):12. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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