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Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes

文献类型：期刊论文

作者Sun, Shaoyan4; Sung, Fengnan1; Wang, Yong2,3
刊名FRONTIERS IN GENETICS
出版日期2019-03-26
卷号10页码:16
关键词type 2 diabetes gene pairwise expression dysfunctional interactions multi-level analysis random walk with restart
ISSN号1664-8021
DOI10.3389/fgene.2019.00252
英文摘要Type 2 diabetes (T2D) is known as a disease caused by gene alterations characterized by insulin resistance, thus the insulin-responsive tissues are of great interest for T2D study. It's of great relevance to systematically investigate commonalities and specificities of T2D among those tissues. Here we establish a multi-level comparative framework across three insulin target tissues (white adipose, skeletal muscle, and liver) to provide a better understanding of T2D. Starting from the ranks of gene expression, we constructed the 'disease network' through detecting diverse interactions to provide a well-characterization for disease affected tissues. Then, we applied random walk with restart algorithm to the disease network to prioritize its nodes and edges according to their association with T2D. Finally, we identified a merged core module by combining the clustering coefficient and Jaccard index, which can provide elaborate and visible illumination of the common and specific features for different tissues at network level. Taken together, our network-, gene-, and module-level characterization across different tissues of T2D hold the promise to provide a broader and deeper understanding for T2D mechanism.
资助项目National Key Research and Development Program of China[2017YFC0908400] ; NSFC[11871463] ; NSFC[61621003] ; NSFC[61671444]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000462601100003
出版者FRONTIERS MEDIA SA
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/34274]  
专题应用数学研究所
通讯作者Sun, Shaoyan; Wang, Yong
作者单位1.Yantaishan Hosp, Clin Lab, Yantai, Peoples R China
2.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, CEMS,NCMIS, Beijing, Peoples R China
4.Ludong Univ, Sch Math & Stat, Yenta, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Shaoyan,Sung, Fengnan,Wang, Yong. Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes[J]. FRONTIERS IN GENETICS,2019,10:16.
APA Sun, Shaoyan,Sung, Fengnan,&Wang, Yong.(2019).Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes.FRONTIERS IN GENETICS,10,16.
MLA Sun, Shaoyan,et al."Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes".FRONTIERS IN GENETICS 10(2019):16.

入库方式： OAI收割

来源：数学与系统科学研究院

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