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A Powerful Method To Test Associations Between Ordinal Traits and Genotypes

文献类型：期刊论文

作者Wang, Jinjuan2,3; Ding, Juan4; Huang, Shouyou1; Li, Qizhai2; Pan, Dongdong5,6
刊名G3-GENES GENOMES GENETICS
出版日期2019-08-01
卷号9期号:8页码:2573-2579
关键词association study ordinal phenotype latent normal variate generalized estimating equation M-estimation
ISSN号2160-1836
DOI10.1534/g3.119.400293
英文摘要The methods commonly used to test the associations between ordinal phenotypes and genotypes often treat either the ordinal phenotype or the genotype as continuous variables. To address limitations of these approaches, we propose a model where both the ordinal phenotype and the genotype are viewed as manifestations of an underlying multivariate normal random variable. The proposed method allows modeling the ordinal phenotype, the genotype and covariates jointly. We employ the generalized estimating equation technique and M-estimation theory to estimate the model parameters and deduce the corresponding asymptotic distribution. Numerical simulations and real data applications are also conducted to compare the performance of the proposed method with those of methods based on the logit and probit models. Even though there may be potential limitations in Type I error rate control for our method, the gains in power can prove its practical value in case of exactly ordinal phenotypes.
资助项目Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; National Nature Science Foundation of China[11661080] ; National Nature Science Foundation of China[11731011] ; National Nature Science Foundation of China[11501134] ; Applied Basic Research Project of Yunnan Province[2017FB002] ; Science and Technology Research Project of the Education Department in Hubei Province[Q20172505]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000479303300018
出版者GENETICS SOCIETY AMERICA
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/35460]  
专题系统科学研究所
通讯作者Li, Qizhai; Pan, Dongdong
作者单位1.Hubei Normal Univ, Sch Math & Stat, Huangshi 435002, Hubei, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, LSC, NCMIS, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Guangxi Normal Univ, Sch Math & Stat, Guilin 541004, Peoples R China
5.Yunnan Univ, Yunnan Key Lab Stat Modeling & Data Anal, Kunming 650500, Yunnan, Peoples R China
6.Yale Univ, Dept Biostat, Sch Publ Hlth, New Haven, CT 06511 USA
推荐引用方式
GB/T 7714		 Wang, Jinjuan,Ding, Juan,Huang, Shouyou,et al. A Powerful Method To Test Associations Between Ordinal Traits and Genotypes[J]. G3-GENES GENOMES GENETICS,2019,9(8):2573-2579.
APA Wang, Jinjuan,Ding, Juan,Huang, Shouyou,Li, Qizhai,&Pan, Dongdong.(2019).A Powerful Method To Test Associations Between Ordinal Traits and Genotypes.G3-GENES GENOMES GENETICS,9(8),2573-2579.
MLA Wang, Jinjuan,et al."A Powerful Method To Test Associations Between Ordinal Traits and Genotypes".G3-GENES GENOMES GENETICS 9.8(2019):2573-2579.

入库方式： OAI收割

来源：数学与系统科学研究院

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