amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation
文献类型：期刊论文
| 作者 | Hu Xiaonan2; Duan Xiaogang3; Pan Dongdong4; Zhang Sanguo2; Li Qizhai1
|
| 刊名 | journalofsystemsscienceandcomplexity
 |
| 出版日期 | 2017 |
| 卷号 | 30期号:1页码:101 |
| ISSN号 | 1009-6124 |
| 英文摘要 | The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test. |
| 语种 | 英语 |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/42206]  |
| 专题 | 系统科学研究所 |
| 作者单位 | 1.中国科学院数学与系统科学研究院 2.中国科学院大学 3.北京师范大学 4.云南大学 |
| 推荐引用方式 GB/T 7714 | Hu Xiaonan,Duan Xiaogang,Pan Dongdong,et al. amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation[J]. journalofsystemsscienceandcomplexity,2017,30(1):101. |
| APA | Hu Xiaonan,Duan Xiaogang,Pan Dongdong,Zhang Sanguo,&Li Qizhai.(2017).amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation.journalofsystemsscienceandcomplexity,30(1),101. |
| MLA | Hu Xiaonan,et al."amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation".journalofsystemsscienceandcomplexity 30.1(2017):101. |
入库方式： OAI收割
来源：数学与系统科学研究院
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