Isolation and sequencing of a new biologically active peptide from human lung carcinoma
文献类型：期刊论文
| 作者 | Hsi, K L; Wu, S X; Chen, Z G; Guo, X Y; Tsou, K |
| 刊名 | Biomedical chromatography : BMC
 |
| 出版日期 | 1986-06 |
| 卷号 | 1期号:3页码:119-22 |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.1130010306 |
| 文献子类 | Article |
| 英文摘要 | A biologically active peptide designated hLCP has been isolated and purified to homogeneity from human lung carcinoma by means of acidic extraction and successive chromatography on Sephadex G-50, Toyopearl HW-40 F and reverse-phase high performance liquid chromatography columns. Analysis showed that peptide consists of thirteen amino acids. Primary structure of hLCP has been deduced by double-coupling Edman degradation combined with enzyme digestion as H-Ser-Pro-Pro-Asp-Gly-Lys-Lys-Glx-Ser-Ala-Asp-Val-Lys-OH. hLCP possessed significant excitatory activity on an electrical stimulation induced contraction. No hLCP could be detected in normal lung tissue. The possibility of using hLCP as a biochemical marker in the clinic for the early detection of lung carcinoma is being investigated. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266284]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Hsi, K L,Wu, S X,Chen, Z G,et al. Isolation and sequencing of a new biologically active peptide from human lung carcinoma[J]. Biomedical chromatography : BMC,1986,1(3):119-22. |
| APA | Hsi, K L,Wu, S X,Chen, Z G,Guo, X Y,&Tsou, K.(1986).Isolation and sequencing of a new biologically active peptide from human lung carcinoma.Biomedical chromatography : BMC,1(3),119-22. |
| MLA | Hsi, K L,et al."Isolation and sequencing of a new biologically active peptide from human lung carcinoma".Biomedical chromatography : BMC 1.3(1986):119-22. |
入库方式： OAI收割
来源：上海药物研究所
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