Effects of tetrahydroprotoberberines on dopamine release and 3,4-dihydroxyphenylacetic acid level in corpus striatum measured by in vivo voltammetry
文献类型：期刊论文
| 作者 | Huang, K X; Sun, B C; Gonon, F G; Jin, G Z |
| 刊名 | Zhongguo yao li xue bao = Acta pharmacologica Sinica
 |
| 出版日期 | 1991-01 |
| 卷号 | 12期号:1页码:32-6 |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The extracellular (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum were measured by in vivo voltammetry to elucidate the effects of 3 tetrahydroprotoberberines on DA neurotransmission. l-tetrahydropalmatine (l-THP, 2 mg.kg-1) or l-stepholidine (l-SPD, 0.5 mg.kg-1) iv increased the striatal DA release by 225% and 233%, respectively; and l-SPD increased the DOPAC level by 70%. Moreover, the enantiomer d-THP (2 mg.kg-1) increased the DA release by 97%, and a large dose of d-THP (20 mg.kg-1) dramatically increased the extracellular DA by 1456% while it slightly elevated the DOPAC level by 123%. These results support the previous ideas that l-SPD and l-THP can block DA receptors and d-THP can deplete neuronal DA. |
| 语种 | 中文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266297]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Huang, K X,Sun, B C,Gonon, F G,et al. Effects of tetrahydroprotoberberines on dopamine release and 3,4-dihydroxyphenylacetic acid level in corpus striatum measured by in vivo voltammetry[J]. Zhongguo yao li xue bao = Acta pharmacologica Sinica,1991,12(1):32-6. |
| APA | Huang, K X,Sun, B C,Gonon, F G,&Jin, G Z.(1991).Effects of tetrahydroprotoberberines on dopamine release and 3,4-dihydroxyphenylacetic acid level in corpus striatum measured by in vivo voltammetry.Zhongguo yao li xue bao = Acta pharmacologica Sinica,12(1),32-6. |
| MLA | Huang, K X,et al."Effects of tetrahydroprotoberberines on dopamine release and 3,4-dihydroxyphenylacetic acid level in corpus striatum measured by in vivo voltammetry".Zhongguo yao li xue bao = Acta pharmacologica Sinica 12.1(1991):32-6. |
入库方式： OAI收割
来源：上海药物研究所
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