Preliminary Study on the Effects of Novel Retinoids SX-115 and CHU-012 on NB4 Cell Line
文献类型：期刊论文
| 作者 | Yao, Yiyun1,2,3,4; Sun, Guanlin; Guo, Zongru; Wu, Weili; Wang, Yun; Su, Hui |
| 刊名 | Zhongguo shi yan xue ye xue za zhi
 |
| 出版日期 | 2000-09 |
| 卷号 | 8期号:3页码:185-188 |
| ISSN号 | 1009-2137 |
| 文献子类 | Article |
| 英文摘要 | In this research, the effects of two new retinoids, SX-115 and CHU-012, on promyelocytic leukemia cell line NB4 were studied in vitro. Cell proliferation, cell morphologic characters, cell cycle kinetics, reduction ability of NBT, differentiation antigens, immunofluorescence staining and RT-PCR were adopted as the observational parameters. The results showed that SX-115 and CHU-012 induced differentiation of NB4 cells at concentration of 10(-6) mol/L. Comparing the effects of the two retinoids with all trans-retinoic acid (ATRA) at same concentration, there was no significant difference among the three agents. The mechanism of the 2 new retinoids remains possibly the same as ATRA. |
| 语种 | 中文 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266349]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China 2.Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China; 3.The 9th People's Hospital, Shanghai Second Medical University, Shanghai 200000, China; 4.Ruijin Hospital, Shanghai Institute of Hematology, Shanghai Second Medical University, Shanghai 200025, China; |
| 推荐引用方式 GB/T 7714 | Yao, Yiyun,Sun, Guanlin,Guo, Zongru,et al. Preliminary Study on the Effects of Novel Retinoids SX-115 and CHU-012 on NB4 Cell Line[J]. Zhongguo shi yan xue ye xue za zhi,2000,8(3):185-188. |
| APA | Yao, Yiyun,Sun, Guanlin,Guo, Zongru,Wu, Weili,Wang, Yun,&Su, Hui.(2000).Preliminary Study on the Effects of Novel Retinoids SX-115 and CHU-012 on NB4 Cell Line.Zhongguo shi yan xue ye xue za zhi,8(3),185-188. |
| MLA | Yao, Yiyun,et al."Preliminary Study on the Effects of Novel Retinoids SX-115 and CHU-012 on NB4 Cell Line".Zhongguo shi yan xue ye xue za zhi 8.3(2000):185-188. |
入库方式： OAI收割
来源：上海药物研究所
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