Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy
文献类型：期刊论文
| 作者 | Zhao, Ting; Zheng, Shan-Song; Zhang, Bin-Feng; Li, Yuan-Yuan; Bligh, S W Annie; Wang, Chang-Hong; Wang, Zheng-Tao |
| 刊名 | Food chemistry
 |
| 出版日期 | 2012-09-15 |
| 卷号 | 134期号:2页码:1096-105 |
| ISSN号 | 1873-7072 |
| DOI | 10.1016/j.foodchem.2012.03.024 |
| 文献子类 | Article |
| 英文摘要 | The β-carboline alkaloids, harmaline and harmine, are present in hallucinogenic plants Ayahuasca and Peganum harmala, and in a variety of foods. In order to establish the metabolic pathway and bioactivities of endogenous and xenobiotic bioactive β-carbolines, high-performance liquid chromatography, coupled with mass spectrometry, was used to identify these metabolites in human liver microsomes (HLMs) in vitro and in rat urine and bile samples after oral administration of the alkaloids. Three metabolites of harmaline and two of harmine were found in the HLMs. Nine metabolites for harmaline and seven metabolites for harmine, from the rat urine and bile samples, were identified. Among them, four in vivo metabolites were isolated and fully characterised by NMR analysis. For the first time, harmaline is shown transforming to harmine by oxidative dehydrogenation in rat. Five metabolic pathways were therefore proposed, namely, oxidative dehydrogenation, 7-O-demethylation, hydroxylation, O-glucuronide conjugation and O-sulphate conjugation. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266363]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China |
| 推荐引用方式 GB/T 7714 | Zhao, Ting,Zheng, Shan-Song,Zhang, Bin-Feng,et al. Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy[J]. Food chemistry,2012,134(2):1096-105. |
| APA | Zhao, Ting.,Zheng, Shan-Song.,Zhang, Bin-Feng.,Li, Yuan-Yuan.,Bligh, S W Annie.,...&Wang, Zheng-Tao.(2012).Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy.Food chemistry,134(2),1096-105. |
| MLA | Zhao, Ting,et al."Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy".Food chemistry 134.2(2012):1096-105. |
入库方式： OAI收割
来源：上海药物研究所
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