The effects of jatrorrhizine on contractile responses of rat ileum
文献类型：期刊论文
| 作者 | Yuan, JianYe; Zhou, JiYan; Hu, ZhiBi; Ji, Guang; Xie, JianQun; Wu, DaZheng |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 663期号:1-3页码:74-9 |
| ISSN号 | 1879-0712 |
| DOI | 10.1016/j.ejphar.2011.05.002 |
| 文献子类 | Article |
| 英文摘要 | This study was designed to evaluate the effect of jatrorrhizine on smooth muscle contractions isolated from rat ileum longitudinal muscles. Jatrorrhizine increased the amplitude of spontaneous contractions of ileum longitudinal muscles in concentration-dependent manner with an EC(50) of 30.0±8.4μM. Preincubation of ileum strips with atropine (1μM), 4-diphenyllacetoxy-N (2-chloriethyl)-piperidine (4-DAMP, 1μM) or darifenacin (1μM) significantly inhibited acetylcholine (0.1μM)- and jatrorrhizine (100μM)-induced ileum longitudinal muscle contractions, whereas they were not affected by AF-DX116 (1μM) or hexamethonium (100μM). Pretreatment with SB204070 (1μM) rather than 3-tropanyl-indole-3-carboxyleat (tropisetron, 1μM) significantly inhibited 5-HT (10μM)-induced ileum longitudinal muscle contractions. In contrast, jatrorrhizine-induced ileum longitudinal muscle contractions were not inhibited by tropisetron or SB204070. Furthermore, jatrorrhizine-induced ileum longitudinal muscle contractions were strongly inhibited by nifedipine (1μM), and also attenuated by removal of extracellular Ca(2+), U73122 (1μM), ruthenium red (50μM) or 2-aminoethoxydiphenylborate (2-APB, 10μM). Taken together, jatrorrhizine-elicited spontaneous contractions in rat ileum longitudinal muscles are mediated by activation of acetylcholine receptors, mostly the M(3) receptor. Ca(2+) influx through L-type Ca(2+) channel is significantly contributed to jatrorrhizine-elicited spontaneous contractions, and Ca(2+) release via IP(3) and ryanodine pathways are also involved. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266386]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Yuan, JianYe,Zhou, JiYan,Hu, ZhiBi,et al. The effects of jatrorrhizine on contractile responses of rat ileum[J]. European journal of pharmacology,2011,663(1-3):74-9. |
| APA | Yuan, JianYe,Zhou, JiYan,Hu, ZhiBi,Ji, Guang,Xie, JianQun,&Wu, DaZheng.(2011).The effects of jatrorrhizine on contractile responses of rat ileum.European journal of pharmacology,663(1-3),74-9. |
| MLA | Yuan, JianYe,et al."The effects of jatrorrhizine on contractile responses of rat ileum".European journal of pharmacology 663.1-3(2011):74-9. |
入库方式： OAI收割
来源：上海药物研究所
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